1P49A

Structure of human placental estrone/dhea sulfatase
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 169
Slipknot S +31

  Help Knotting data interpretation Full screen
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 10-320 311 1-9 357-553 321-356 9 197 slipknot
Chain Sequence
AASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPL-TPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVC----FATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDRE
Whole chain analysis

  Help Knotoid data interpretation Full screen
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


  Help Knotoid subchains data interpretation Full screen
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 6-317 312 1-5 322-548 318-321 5 227 slipknot
view details
3.1 10-320 311 1-9 342-548 321-341 9 207 slipknot
view details
3.1 7-353 347 1-6 357-548 354-356 6 192 slipknot
view details
2.1 9-345 337 1-5, 354-548 6-8, 346-353 5 195 slipknot
sequence length 553
structure length 548
publication title Structure of Human Estrone Sulfatase Suggests Functional Roles of Membrane Association
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords STERYL-SULFATASE
missing residues 53, 455-458
total genus Genus: 169
ec nomenclature ec 3.1.6.2: Steryl-sulfatase.
pdb deposition date 2003-04-21
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00884 Sulfatase Sulfatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.287.550 Mainly Alpha Orthogonal Bundle Helix Hairpins Helix hairpin bin 1p49A02
3.30.1120.10 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 1p49A03
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1p49A01
1P49A 1KH4A 1SHQA 3OT9A 3T01A 3DPCA 2IFYA 3T02A 1EW8A 1AJAA 1ALJA 1FSUA 1O99A 1ZEDA 3IGZB 2QZUA 2G9YA 1KHKA 1ELXA 4FDIA 1AJCA 1ED9A 3ED4A 1KH5A 1AUKA 1AJDA 1HJKA 3BDGB 1EW2A 1EQJA 1AJBA 1O98A 1URAA 1KH9A 3TX0A 1ALKA 1KHJA 2GA3A 3NVLA 3T00A 3M7VA 1KHLA 3TWZA 1ZEBA 1EI6A 4FDJA 3SZYA 1EJJA 3DYCA 3UN3A 1KH7A 3MK1A 3M8YA 1Y7AA 1ANJA 3MK2A 1ELZA 2GLQA 1N2LA 1KHNA 1SHNA 1N2KA 1E2SP 3BDGA 1K7HA 2ANHA 1HQAA 3M8WA 3UO0A 1ELYA 3BDFA 1ZEFA 1EW9A 3MK0A 1Y6VA 3UN2A 1E3CP 3M8ZA 3SZZA 3UN5A 1B8JA 3IGYB 1ED8A 1E1ZP 1ALIA 1E33P 1URBA 1HDHA 1ANIA 3BDHA 3CMRA 3UNYA
chains in the KnotProt database with same CATH superfamily
1P49A 1KH4A 1SHQA 3OT9A 3T01A 3DPCA 2IFYA 3T02A 1EW8A 1AJAA 1ALJA 1FSUA 1O99A 1ZEDA 3IGZB 2QZUA 2G9YA 1KHKA 1ELXA 1JCHA 4FDIA 1AJCA 1ED9A 3ED4A 1KH5A 1AUKA 1AJDA 1HJKA 3BDGB 1EW2A 1EQJA 1AJBA 1O98A 1URAA 1KH9A 3TX0A 1ALKA 1KHJA 2GA3A 3NVLA 3T00A 3M7VA 1KHLA 3TWZA 1ZEBA 1EI6A 4FDJA 3SZYA 1EJJA 3DYCA 3UN3A 1KH7A 3MK1A 3M8YA 1Y7AA 1ANJA 3MK2A 1ELZA 2GLQA 1N2LA 1KHNA 1SHNA 1N2KA 1E2SP 3BDGA 1K7HA 2ANHA 1HQAA 3M8WA 3UO0A 2B5UA 1ELYA 3BDFA 1ZEFA 1EW9A 3MK0A 1Y6VA 3UN2A 1E3CP 3M8ZA 3SZZA 3UN5A 1B8JA 3IGYB 1ED8A 1E1ZP 1ALIA 1E33P 1URBA 1HDHA 1ANIA 3BDHA 3CMRA 3UNYA
chains in the KnotProt database with same CATH topology
1P49A 1KH4A 1SHQA 3OT9A 3T01A 3DPCA 2IFYA 3T02A 1EW8A 1AJAA 1ALJA 1FSUA 1O99A 1ZEDA 3IGZB 2QZUA 2G9YA 1KHKA 1ELXA 4FDIA 1AJCA 1ED9A 3ED4A 1KH5A 1AUKA 1AJDA 1HJKA 3BDGB 1EW2A 1EQJA 1AJBA 1O98A 1URAA 1KH9A 3TX0A 1ALKA 1KHJA 2GA3A 3NVLA 3T00A 3M7VA 1KHLA 3TWZA 1ZEBA 1EI6A 4FDJA 3SZYA 1EJJA 3DYCA 3UN3A 1KH7A 3MK1A 3M8YA 1Y7AA 1ANJA 3MK2A 1ELZA 2GLQA 1N2LA 1KHNA 1SHNA 1N2KA 1E2SP 3BDGA 1K7HA 2ANHA 1HQAA 3M8WA 3UO0A 1ELYA 3BDFA 1ZEFA 1EW9A 3MK0A 1Y6VA 3UN2A 1E3CP 3M8ZA 3SZZA 3UN5A 1B8JA 3IGYB 1ED8A 1E1ZP 1ALIA 1E33P 1URBA 1HDHA 1ANIA 3BDHA 3CMRA 3UNYA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1P49 A;  1KH4 A;  1SHQ A;  3OT9 A;  3T01 A;  3DPC A;  2IFY A;  3T02 A;  1EW8 A;  1AJA A;  1ALJ A;  1FSU A;  1O99 A;  1ZED A;  3IGZ B;  2QZU A;  2G9Y A;  1KHK A;  1ELX A;  4FDI A;  1AJC A;  1ED9 A;  3ED4 A;  1KH5 A;  1AUK A;  1AJD A;  1HJK A;  3BDG B;  1EW2 A;  1EQJ A;  1AJB A;  1O98 A;  1URA A;  1KH9 A;  3TX0 A;  1ALK A;  1KHJ A;  2GA3 A;  3NVL A;  3T00 A;  3M7V A;  1KHL A;  3TWZ A;  1ZEB A;  1EI6 A;  4FDJ A;  3SZY A;  1EJJ A;  3DYC A;  3UN3 A;  1KH7 A;  3MK1 A;  3M8Y A;  1Y7A A;  1ANJ A;  3MK2 A;  1ELZ A;  2GLQ A;  1N2L A;  1KHN A;  1SHN A;  1N2K A;  1E2S P;  3BDG A;  1K7H A;  2ANH A;  1HQA A;  3M8W A;  3UO0 A;  1ELY A;  3BDF A;  1ZEF A;  1EW9 A;  3MK0 A;  1Y6V A;  3UN2 A;  1E3C P;  3M8Z A;  3SZZ A;  3UN5 A;  1B8J A;  3IGY B;  1ED8 A;  1E1Z P;  1ALI A;  1E33 P;  1URB A;  1HDH A;  1ANI A;  3BDH A;  3CMR A;  3UNY A; 
#chains in the KnotProt database with same CATH topology
 1P49 A;  1KH4 A;  1SHQ A;  3OT9 A;  3T01 A;  3DPC A;  2IFY A;  3T02 A;  1EW8 A;  1AJA A;  1ALJ A;  1FSU A;  1O99 A;  1ZED A;  3IGZ B;  2QZU A;  2G9Y A;  1KHK A;  1ELX A;  1JCH A;  4FDI A;  1AJC A;  1ED9 A;  3ED4 A;  1KH5 A;  1AUK A;  1AJD A;  1HJK A;  3BDG B;  1EW2 A;  1EQJ A;  1AJB A;  1O98 A;  1URA A;  1KH9 A;  3TX0 A;  1ALK A;  1KHJ A;  2GA3 A;  3NVL A;  3T00 A;  3M7V A;  1KHL A;  3TWZ A;  1ZEB A;  1EI6 A;  4FDJ A;  3SZY A;  1EJJ A;  3DYC A;  3UN3 A;  1KH7 A;  3MK1 A;  3M8Y A;  1Y7A A;  1ANJ A;  3MK2 A;  1ELZ A;  2GLQ A;  1N2L A;  1KHN A;  1SHN A;  1N2K A;  1E2S P;  3BDG A;  1K7H A;  2ANH A;  1HQA A;  3M8W A;  3UO0 A;  2B5U A;  1ELY A;  3BDF A;  1ZEF A;  1EW9 A;  3MK0 A;  1Y6V A;  3UN2 A;  1E3C P;  3M8Z A;  3SZZ A;  3UN5 A;  1B8J A;  3IGY B;  1ED8 A;  1E1Z P;  1ALI A;  1E33 P;  1URB A;  1HDH A;  1ANI A;  3BDH A;  3CMR A;  3UNY A; 
#chains in the KnotProt database with same CATH homology
 1P49 A;  1KH4 A;  1SHQ A;  3OT9 A;  3T01 A;  3DPC A;  2IFY A;  3T02 A;  1EW8 A;  1AJA A;  1ALJ A;  1FSU A;  1O99 A;  1ZED A;  3IGZ B;  2QZU A;  2G9Y A;  1KHK A;  1ELX A;  4FDI A;  1AJC A;  1ED9 A;  3ED4 A;  1KH5 A;  1AUK A;  1AJD A;  1HJK A;  3BDG B;  1EW2 A;  1EQJ A;  1AJB A;  1O98 A;  1URA A;  1KH9 A;  3TX0 A;  1ALK A;  1KHJ A;  2GA3 A;  3NVL A;  3T00 A;  3M7V A;  1KHL A;  3TWZ A;  1ZEB A;  1EI6 A;  4FDJ A;  3SZY A;  1EJJ A;  3DYC A;  3UN3 A;  1KH7 A;  3MK1 A;  3M8Y A;  1Y7A A;  1ANJ A;  3MK2 A;  1ELZ A;  2GLQ A;  1N2L A;  1KHN A;  1SHN A;  1N2K A;  1E2S P;  3BDG A;  1K7H A;  2ANH A;  1HQA A;  3M8W A;  3UO0 A;  1ELY A;  3BDF A;  1ZEF A;  1EW9 A;  3MK0 A;  1Y6V A;  3UN2 A;  1E3C P;  3M8Z A;  3SZZ A;  3UN5 A;  1B8J A;  3IGY B;  1ED8 A;  1E1Z P;  1ALI A;  1E33 P;  1URB A;  1HDH A;  1ANI A;  3BDH A;  3CMR A;  3UNY A;
...loading similar chains, please wait...
similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...
How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling