1P49A

Structure of human placental estrone/dhea sulfatase
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 10-320 311 1-9 357-553 321-356 9 197 slipknot
Chain Sequence
AASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPL-TPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVC----FATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDRE
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 6-317 312 1-5 322-548 318-321 5 227 slipknot
view details
3.1 10-320 311 1-9 342-548 321-341 9 207 slipknot
view details
3.1 7-353 347 1-6 357-548 354-356 6 192 slipknot
view details
2.1 9-345 337 1-5, 354-548 6-8, 346-353 5 195 slipknot
sequence length 553
structure length 548
publication title Structure of Human Estrone Sulfatase Suggests Functional Roles of Membrane Association
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords STERYL-SULFATASE
missing residues 53, 455-458
total genus Genus: 169
ec nomenclature ec 3.1.6.2: Steryl-sulfatase.
pdb deposition date 2003-04-21
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00884 Sulfatase Sulfatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.287.550 Mainly Alpha Orthogonal Bundle Helix Hairpins Helix hairpin bin 1p49A02
3.30.1120.10 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 1p49A03
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1p49A01
1KHNA 3ED4A 3M8YA 3IGYB 3OT9A 3M8ZA 1O98A 2QZUA 3T01A 3M8WA 3BDGA 1EW9A 1ZEBA 1KHJA 1ZEFA 1EI6A 2G9YA 1AJAA 3SZYA 1Y6VA 3UO0A 1K7HA 1HJKA 1EW8A 1KH5A 1AJDA 1P49A 1ELYA 1ELXA 3MK1A 1B8JA 2ANHA 3BDGB 4FDJA 3UN2A 1ED9A 1ALIA 1Y7AA 3MK0A 1ED8A 3SZZA 1HQAA 1KH4A 1AJCA 1EW2A 1ZEDA 2IFYA 1EJJA 1ELZA 3MK2A 3NVLA 1ALKA 3DYCA 1AJBA 1N2LA 1E1ZP 3BDFA 3T02A 1ANJA 3T00A 1FSUA 3TWZA 3UN5A 3UNYA 2GA3A 1E3CP 1SHNA 1EQJA 1KH7A 3BDHA 3DPCA 1KH9A 1ANIA 3TX0A 1KHKA 1KHLA 1O99A 1SHQA 1AUKA 1URBA 1E2SP 3CMRA 1ALJA 1URAA 3IGZB 1HDHA 1N2KA 3M7VA 1E33P 2GLQA 3UN3A 4FDIA
chains in the KnotProt database with same CATH superfamily
1KHNA 3ED4A 3M8YA 3IGYB 3OT9A 1JCHA 3M8ZA 1O98A 2QZUA 3T01A 3M8WA 3BDGA 1EW9A 1ZEBA 1KHJA 1ZEFA 1EI6A 2G9YA 1AJAA 3SZYA 1Y6VA 3UO0A 1K7HA 1HJKA 1EW8A 1KH5A 1AJDA 1P49A 1ELYA 1ELXA 3MK1A 1B8JA 2ANHA 3BDGB 4FDJA 3UN2A 1ED9A 1ALIA 1Y7AA 3MK0A 1ED8A 3SZZA 1HQAA 1KH4A 1AJCA 1EW2A 1ZEDA 2IFYA 1EJJA 1ELZA 3MK2A 3NVLA 1ALKA 3DYCA 1AJBA 1N2LA 1E1ZP 3BDFA 3T02A 1ANJA 3T00A 1FSUA 3TWZA 3UN5A 3UNYA 2GA3A 1E3CP 1SHNA 1EQJA 1KH7A 3BDHA 3DPCA 1KH9A 1ANIA 3TX0A 1KHKA 1KHLA 1O99A 1SHQA 1AUKA 1URBA 1E2SP 3CMRA 1ALJA 1URAA 3IGZB 1HDHA 2B5UA 1N2KA 3M7VA 1E33P 2GLQA 3UN3A 4FDIA
chains in the KnotProt database with same CATH topology
1KHNA 3ED4A 3M8YA 3IGYB 3OT9A 3M8ZA 1O98A 2QZUA 3T01A 3M8WA 3BDGA 1EW9A 1ZEBA 1KHJA 1ZEFA 1EI6A 2G9YA 1AJAA 3SZYA 1Y6VA 3UO0A 1K7HA 1HJKA 1EW8A 1KH5A 1AJDA 1P49A 1ELYA 1ELXA 3MK1A 1B8JA 2ANHA 3BDGB 4FDJA 3UN2A 1ED9A 1ALIA 1Y7AA 3MK0A 1ED8A 3SZZA 1HQAA 1KH4A 1AJCA 1EW2A 1ZEDA 2IFYA 1EJJA 1ELZA 3MK2A 3NVLA 1ALKA 3DYCA 1AJBA 1N2LA 1E1ZP 3BDFA 3T02A 1ANJA 3T00A 1FSUA 3TWZA 3UN5A 3UNYA 2GA3A 1E3CP 1SHNA 1EQJA 1KH7A 3BDHA 3DPCA 1KH9A 1ANIA 3TX0A 1KHKA 1KHLA 1O99A 1SHQA 1AUKA 1URBA 1E2SP 3CMRA 1ALJA 1URAA 3IGZB 1HDHA 1N2KA 3M7VA 1E33P 2GLQA 3UN3A 4FDIA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1KHN A;  3ED4 A;  3M8Y A;  3IGY B;  3OT9 A;  3M8Z A;  1O98 A;  2QZU A;  3T01 A;  3M8W A;  3BDG A;  1EW9 A;  1ZEB A;  1KHJ A;  1ZEF A;  1EI6 A;  2G9Y A;  1AJA A;  3SZY A;  1Y6V A;  3UO0 A;  1K7H A;  1HJK A;  1EW8 A;  1KH5 A;  1AJD A;  1P49 A;  1ELY A;  1ELX A;  3MK1 A;  1B8J A;  2ANH A;  3BDG B;  4FDJ A;  3UN2 A;  1ED9 A;  1ALI A;  1Y7A A;  3MK0 A;  1ED8 A;  3SZZ A;  1HQA A;  1KH4 A;  1AJC A;  1EW2 A;  1ZED A;  2IFY A;  1EJJ A;  1ELZ A;  3MK2 A;  3NVL A;  1ALK A;  3DYC A;  1AJB A;  1N2L A;  1E1Z P;  3BDF A;  3T02 A;  1ANJ A;  3T00 A;  1FSU A;  3TWZ A;  3UN5 A;  3UNY A;  2GA3 A;  1E3C P;  1SHN A;  1EQJ A;  1KH7 A;  3BDH A;  3DPC A;  1KH9 A;  1ANI A;  3TX0 A;  1KHK A;  1KHL A;  1O99 A;  1SHQ A;  1AUK A;  1URB A;  1E2S P;  3CMR A;  1ALJ A;  1URA A;  3IGZ B;  1HDH A;  1N2K A;  3M7V A;  1E33 P;  2GLQ A;  3UN3 A;  4FDI A; 
#chains in the KnotProt database with same CATH topology
 1KHN A;  3ED4 A;  3M8Y A;  3IGY B;  3OT9 A;  1JCH A;  3M8Z A;  1O98 A;  2QZU A;  3T01 A;  3M8W A;  3BDG A;  1EW9 A;  1ZEB A;  1KHJ A;  1ZEF A;  1EI6 A;  2G9Y A;  1AJA A;  3SZY A;  1Y6V A;  3UO0 A;  1K7H A;  1HJK A;  1EW8 A;  1KH5 A;  1AJD A;  1P49 A;  1ELY A;  1ELX A;  3MK1 A;  1B8J A;  2ANH A;  3BDG B;  4FDJ A;  3UN2 A;  1ED9 A;  1ALI A;  1Y7A A;  3MK0 A;  1ED8 A;  3SZZ A;  1HQA A;  1KH4 A;  1AJC A;  1EW2 A;  1ZED A;  2IFY A;  1EJJ A;  1ELZ A;  3MK2 A;  3NVL A;  1ALK A;  3DYC A;  1AJB A;  1N2L A;  1E1Z P;  3BDF A;  3T02 A;  1ANJ A;  3T00 A;  1FSU A;  3TWZ A;  3UN5 A;  3UNY A;  2GA3 A;  1E3C P;  1SHN A;  1EQJ A;  1KH7 A;  3BDH A;  3DPC A;  1KH9 A;  1ANI A;  3TX0 A;  1KHK A;  1KHL A;  1O99 A;  1SHQ A;  1AUK A;  1URB A;  1E2S P;  3CMR A;  1ALJ A;  1URA A;  3IGZ B;  1HDH A;  2B5U A;  1N2K A;  3M7V A;  1E33 P;  2GLQ A;  3UN3 A;  4FDI A; 
#chains in the KnotProt database with same CATH homology
 1KHN A;  3ED4 A;  3M8Y A;  3IGY B;  3OT9 A;  3M8Z A;  1O98 A;  2QZU A;  3T01 A;  3M8W A;  3BDG A;  1EW9 A;  1ZEB A;  1KHJ A;  1ZEF A;  1EI6 A;  2G9Y A;  1AJA A;  3SZY A;  1Y6V A;  3UO0 A;  1K7H A;  1HJK A;  1EW8 A;  1KH5 A;  1AJD A;  1P49 A;  1ELY A;  1ELX A;  3MK1 A;  1B8J A;  2ANH A;  3BDG B;  4FDJ A;  3UN2 A;  1ED9 A;  1ALI A;  1Y7A A;  3MK0 A;  1ED8 A;  3SZZ A;  1HQA A;  1KH4 A;  1AJC A;  1EW2 A;  1ZED A;  2IFY A;  1EJJ A;  1ELZ A;  3MK2 A;  3NVL A;  1ALK A;  3DYC A;  1AJB A;  1N2L A;  1E1Z P;  3BDF A;  3T02 A;  1ANJ A;  3T00 A;  1FSU A;  3TWZ A;  3UN5 A;  3UNY A;  2GA3 A;  1E3C P;  1SHN A;  1EQJ A;  1KH7 A;  3BDH A;  3DPC A;  1KH9 A;  1ANI A;  3TX0 A;  1KHK A;  1KHL A;  1O99 A;  1SHQ A;  1AUK A;  1URB A;  1E2S P;  3CMR A;  1ALJ A;  1URA A;  3IGZ B;  1HDH A;  1N2K A;  3M7V A;  1E33 P;  2GLQ A;  3UN3 A;  4FDI A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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