1P49A

Structure of human placental estrone/dhea sulfatase
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 169
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 10-320 311 1-9 357-553 321-356 9 197 slipknot
Chain Sequence
AASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPL-TPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVC----FATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDRE
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 6-317 312 1-5 322-548 318-321 5 227 slipknot
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3.1 10-320 311 1-9 342-548 321-341 9 207 slipknot
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3.1 7-353 347 1-6 357-548 354-356 6 192 slipknot
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2.1 9-345 337 1-5, 354-548 6-8, 346-353 5 195 slipknot
sequence length 553
structure length 548
publication title Structure of Human Estrone Sulfatase Suggests Functional Roles of Membrane Association
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords STERYL-SULFATASE
missing residues 53, 455-458
total genus Genus: 169
ec nomenclature ec 3.1.6.2: Steryl-sulfatase.
pdb deposition date 2003-04-21
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00884 Sulfatase Sulfatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.287.550 Mainly Alpha Orthogonal Bundle Helix Hairpins Helix hairpin bin 1p49A02
3.30.1120.10 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 1p49A03
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1p49A01
3T01A 1KH4A 2QZUA 2GLQA 3UN5A 3DYCA 3M8YA 3SZZA 1AJBA 1SHNA 1EJJA 1K7HA 1O99A 3BDFA 1HQAA 3NVLA 1AJAA 1O98A 1ANIA 1URBA 1E2SP 1ZEFA 3UN2A 1EQJA 3T02A 1EW8A 1KH7A 3TX0A 4FDJA 1N2KA 1AJDA 1HJKA 1ALKA 1KH5A 3UN3A 1ELZA 1KHKA 1KHNA 1SHQA 3MK1A 1E1ZP 1ELYA 3CMRA 3OT9A 2G9YA 3MK0A 3M8ZA 3SZYA 1Y6VA 3ED4A 3BDHA 1URAA 3M8WA 3UO0A 3BDGB 1ED8A 1E33P 1B8JA 4FDIA 1ZEBA 3T00A 3UNYA 1EW2A 1E3CP 1AJCA 3MK2A 1P49A 3DPCA 2GA3A 3IGZB 1EI6A 1ZEDA 1KH9A 1ALIA 3M7VA 1KHJA 1HDHA 3TWZA 3IGYB 1EW9A 2ANHA 2IFYA 1AUKA 1ALJA 1FSUA 1ED9A 1ELXA 1Y7AA 1ANJA 3BDGA 1N2LA 1KHLA
chains in the KnotProt database with same CATH superfamily
3T01A 1KH4A 2QZUA 2GLQA 3UN5A 3DYCA 3M8YA 3SZZA 1AJBA 1SHNA 1JCHA 1EJJA 1K7HA 1O99A 3BDFA 1HQAA 3NVLA 1AJAA 1O98A 1ANIA 1URBA 1E2SP 1ZEFA 3UN2A 2B5UA 1EQJA 3T02A 1EW8A 1KH7A 3TX0A 4FDJA 1N2KA 1AJDA 1HJKA 1ALKA 1KH5A 3UN3A 1ELZA 1KHKA 1KHNA 1SHQA 3MK1A 1E1ZP 1ELYA 3CMRA 3OT9A 2G9YA 3MK0A 3M8ZA 3SZYA 1Y6VA 3ED4A 3BDHA 1URAA 3M8WA 3UO0A 3BDGB 1ED8A 1E33P 1B8JA 4FDIA 1ZEBA 3T00A 3UNYA 1EW2A 1E3CP 1AJCA 3MK2A 1P49A 3DPCA 2GA3A 3IGZB 1EI6A 1ZEDA 1KH9A 1ALIA 3M7VA 1KHJA 1HDHA 3TWZA 3IGYB 1EW9A 2ANHA 2IFYA 1AUKA 1ALJA 1FSUA 1ED9A 1ELXA 1Y7AA 1ANJA 3BDGA 1N2LA 1KHLA
chains in the KnotProt database with same CATH topology
3T01A 1KH4A 2QZUA 2GLQA 3UN5A 3DYCA 3M8YA 3SZZA 1AJBA 1SHNA 1EJJA 1K7HA 1O99A 3BDFA 1HQAA 3NVLA 1AJAA 1O98A 1ANIA 1URBA 1E2SP 1ZEFA 3UN2A 1EQJA 3T02A 1EW8A 1KH7A 3TX0A 4FDJA 1N2KA 1AJDA 1HJKA 1ALKA 1KH5A 3UN3A 1ELZA 1KHKA 1KHNA 1SHQA 3MK1A 1E1ZP 1ELYA 3CMRA 3OT9A 2G9YA 3MK0A 3M8ZA 3SZYA 1Y6VA 3ED4A 3BDHA 1URAA 3M8WA 3UO0A 3BDGB 1ED8A 1E33P 1B8JA 4FDIA 1ZEBA 3T00A 3UNYA 1EW2A 1E3CP 1AJCA 3MK2A 1P49A 3DPCA 2GA3A 3IGZB 1EI6A 1ZEDA 1KH9A 1ALIA 3M7VA 1KHJA 1HDHA 3TWZA 3IGYB 1EW9A 2ANHA 2IFYA 1AUKA 1ALJA 1FSUA 1ED9A 1ELXA 1Y7AA 1ANJA 3BDGA 1N2LA 1KHLA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 3T01 A;  1KH4 A;  2QZU A;  2GLQ A;  3UN5 A;  3DYC A;  3M8Y A;  3SZZ A;  1AJB A;  1SHN A;  1EJJ A;  1K7H A;  1O99 A;  3BDF A;  1HQA A;  3NVL A;  1AJA A;  1O98 A;  1ANI A;  1URB A;  1E2S P;  1ZEF A;  3UN2 A;  1EQJ A;  3T02 A;  1EW8 A;  1KH7 A;  3TX0 A;  4FDJ A;  1N2K A;  1AJD A;  1HJK A;  1ALK A;  1KH5 A;  3UN3 A;  1ELZ A;  1KHK A;  1KHN A;  1SHQ A;  3MK1 A;  1E1Z P;  1ELY A;  3CMR A;  3OT9 A;  2G9Y A;  3MK0 A;  3M8Z A;  3SZY A;  1Y6V A;  3ED4 A;  3BDH A;  1URA A;  3M8W A;  3UO0 A;  3BDG B;  1ED8 A;  1E33 P;  1B8J A;  4FDI A;  1ZEB A;  3T00 A;  3UNY A;  1EW2 A;  1E3C P;  1AJC A;  3MK2 A;  1P49 A;  3DPC A;  2GA3 A;  3IGZ B;  1EI6 A;  1ZED A;  1KH9 A;  1ALI A;  3M7V A;  1KHJ A;  1HDH A;  3TWZ A;  3IGY B;  1EW9 A;  2ANH A;  2IFY A;  1AUK A;  1ALJ A;  1FSU A;  1ED9 A;  1ELX A;  1Y7A A;  1ANJ A;  3BDG A;  1N2L A;  1KHL A; 
#chains in the KnotProt database with same CATH topology
 3T01 A;  1KH4 A;  2QZU A;  2GLQ A;  3UN5 A;  3DYC A;  3M8Y A;  3SZZ A;  1AJB A;  1SHN A;  1JCH A;  1EJJ A;  1K7H A;  1O99 A;  3BDF A;  1HQA A;  3NVL A;  1AJA A;  1O98 A;  1ANI A;  1URB A;  1E2S P;  1ZEF A;  3UN2 A;  2B5U A;  1EQJ A;  3T02 A;  1EW8 A;  1KH7 A;  3TX0 A;  4FDJ A;  1N2K A;  1AJD A;  1HJK A;  1ALK A;  1KH5 A;  3UN3 A;  1ELZ A;  1KHK A;  1KHN A;  1SHQ A;  3MK1 A;  1E1Z P;  1ELY A;  3CMR A;  3OT9 A;  2G9Y A;  3MK0 A;  3M8Z A;  3SZY A;  1Y6V A;  3ED4 A;  3BDH A;  1URA A;  3M8W A;  3UO0 A;  3BDG B;  1ED8 A;  1E33 P;  1B8J A;  4FDI A;  1ZEB A;  3T00 A;  3UNY A;  1EW2 A;  1E3C P;  1AJC A;  3MK2 A;  1P49 A;  3DPC A;  2GA3 A;  3IGZ B;  1EI6 A;  1ZED A;  1KH9 A;  1ALI A;  3M7V A;  1KHJ A;  1HDH A;  3TWZ A;  3IGY B;  1EW9 A;  2ANH A;  2IFY A;  1AUK A;  1ALJ A;  1FSU A;  1ED9 A;  1ELX A;  1Y7A A;  1ANJ A;  3BDG A;  1N2L A;  1KHL A; 
#chains in the KnotProt database with same CATH homology
 3T01 A;  1KH4 A;  2QZU A;  2GLQ A;  3UN5 A;  3DYC A;  3M8Y A;  3SZZ A;  1AJB A;  1SHN A;  1EJJ A;  1K7H A;  1O99 A;  3BDF A;  1HQA A;  3NVL A;  1AJA A;  1O98 A;  1ANI A;  1URB A;  1E2S P;  1ZEF A;  3UN2 A;  1EQJ A;  3T02 A;  1EW8 A;  1KH7 A;  3TX0 A;  4FDJ A;  1N2K A;  1AJD A;  1HJK A;  1ALK A;  1KH5 A;  3UN3 A;  1ELZ A;  1KHK A;  1KHN A;  1SHQ A;  3MK1 A;  1E1Z P;  1ELY A;  3CMR A;  3OT9 A;  2G9Y A;  3MK0 A;  3M8Z A;  3SZY A;  1Y6V A;  3ED4 A;  3BDH A;  1URA A;  3M8W A;  3UO0 A;  3BDG B;  1ED8 A;  1E33 P;  1B8J A;  4FDI A;  1ZEB A;  3T00 A;  3UNY A;  1EW2 A;  1E3C P;  1AJC A;  3MK2 A;  1P49 A;  3DPC A;  2GA3 A;  3IGZ B;  1EI6 A;  1ZED A;  1KH9 A;  1ALI A;  3M7V A;  1KHJ A;  1HDH A;  3TWZ A;  3IGY B;  1EW9 A;  2ANH A;  2IFY A;  1AUK A;  1ALJ A;  1FSU A;  1ED9 A;  1ELX A;  1Y7A A;  1ANJ A;  3BDG A;  1N2L A;  1KHL A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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