1ZEFA

Structure of alkaline phosphatase from human placenta in complex with its uncompetitive inhibitor l-phe
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 40-355 316 1-39 440-481 356-439 39 42 slipknot
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 35-355 321 1-34 362-481 356-361 34 120 slipknot
view details
3.1 39-358 320 1-38 437-481 359-436 38 45 slipknot
view details
2.1 36-436 401 1-35 441-481 437-440 35 41 slipknot
view details
2.1 40-404 365 1-38, 413-481 39-39, 405-412 38 69 slipknot
view details
2.1 41-403 363 1-39, 413-481 40-40, 404-412 39 69 slipknot
sequence length 481
structure length 481
publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus Genus: 176
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zefA00
1ALKA 1ALIA 1ANJA 1ELXA 1AJDA 3T00A 3IGZB 3BDGB 1EW2A 3MK2A 1KH7A 1URAA 3UN2A 1O99A 1KH5A 1HQAA 1O98A 1ZEBA 1EW8A 3MK1A 3MK0A 1E33P 3SZZA 1B8JA 3UN5A 1SHQA 3BDGA 3DPCA 1E1ZP 1AJAA 2IFYA 1EI6A 3M8YA 1ED9A 1KHJA 1URBA 1Y7AA 1P49A 3UO0A 1E3CP 1SHNA 1AJBA 3UNYA 1KHKA 3OT9A 1AUKA 1KHLA 1EW9A 3UN3A 1ED8A 1HJKA 2ANHA 3CMRA 1E2SP 1FSUA 2G9YA 3M8ZA 2QZUA 3IGYB 1K7HA 1ANIA 1ELZA 1AJCA 4FDIA 3DYCA 2GLQA 1N2KA 1KH4A 3M7VA 1N2LA 1ALJA 3BDFA 3T01A 1HDHA 4FDJA 3ED4A 1KH9A 1EQJA 1ELYA 1KHNA 1ZEFA 2GA3A 3M8WA 3SZYA 1EJJA 1Y6VA 3TX0A 3BDHA 3NVLA 3TWZA 3T02A 1ZEDA
chains in the KnotProt database with same CATH superfamily
1ALKA 1ALIA 1ANJA 1ELXA 1AJDA 3T00A 3IGZB 3BDGB 1EW2A 3MK2A 1KH7A 1URAA 3UN2A 1O99A 1KH5A 1HQAA 1O98A 1ZEBA 1EW8A 3MK1A 3MK0A 1E33P 3SZZA 1B8JA 3UN5A 1SHQA 3BDGA 3DPCA 1E1ZP 1AJAA 2IFYA 1EI6A 3M8YA 1ED9A 1KHJA 1URBA 1Y7AA 1P49A 3UO0A 1E3CP 1SHNA 1AJBA 3UNYA 1KHKA 3OT9A 1AUKA 1KHLA 1EW9A 3UN3A 1ED8A 1HJKA 2ANHA 3CMRA 1E2SP 1FSUA 2G9YA 3M8ZA 2QZUA 3IGYB 1K7HA 1ANIA 1ELZA 1AJCA 4FDIA 3DYCA 2GLQA 1N2KA 1KH4A 3M7VA 1N2LA 1ALJA 3BDFA 3T01A 1HDHA 4FDJA 3ED4A 1KH9A 1EQJA 1ELYA 1KHNA 1ZEFA 2GA3A 3M8WA 3SZYA 1EJJA 1Y6VA 3TX0A 3BDHA 3NVLA 3TWZA 3T02A 1ZEDA
chains in the KnotProt database with same CATH topology
1ALKA 1ALIA 1ANJA 1ELXA 1AJDA 3T00A 3IGZB 3BDGB 1EW2A 3MK2A 1KH7A 1URAA 3UN2A 1O99A 1KH5A 1HQAA 1O98A 1ZEBA 1EW8A 3MK1A 3MK0A 1E33P 3SZZA 1B8JA 3UN5A 1SHQA 3BDGA 3DPCA 1E1ZP 1AJAA 2IFYA 1EI6A 3M8YA 1ED9A 1KHJA 1URBA 1Y7AA 1P49A 3UO0A 1E3CP 1SHNA 1AJBA 3UNYA 1KHKA 3OT9A 1AUKA 1KHLA 1EW9A 3UN3A 1ED8A 1HJKA 2ANHA 3CMRA 1E2SP 1FSUA 2G9YA 3M8ZA 2QZUA 3IGYB 1K7HA 1ANIA 1ELZA 1AJCA 4FDIA 3DYCA 2GLQA 1N2KA 1KH4A 3M7VA 1N2LA 1ALJA 3BDFA 3T01A 1HDHA 4FDJA 3ED4A 1KH9A 1EQJA 1ELYA 1KHNA 1ZEFA 2GA3A 3M8WA 3SZYA 1EJJA 1Y6VA 3TX0A 3BDHA 3NVLA 3TWZA 3T02A 1ZEDA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1ALK A;  1ALI A;  1ANJ A;  1ELX A;  1AJD A;  3T00 A;  3IGZ B;  3BDG B;  1EW2 A;  3MK2 A;  1KH7 A;  1URA A;  3UN2 A;  1O99 A;  1KH5 A;  1HQA A;  1O98 A;  1ZEB A;  1EW8 A;  3MK1 A;  3MK0 A;  1E33 P;  3SZZ A;  1B8J A;  3UN5 A;  1SHQ A;  3BDG A;  3DPC A;  1E1Z P;  1AJA A;  2IFY A;  1EI6 A;  3M8Y A;  1ED9 A;  1KHJ A;  1URB A;  1Y7A A;  1P49 A;  3UO0 A;  1E3C P;  1SHN A;  1AJB A;  3UNY A;  1KHK A;  3OT9 A;  1AUK A;  1KHL A;  1EW9 A;  3UN3 A;  1ED8 A;  1HJK A;  2ANH A;  3CMR A;  1E2S P;  1FSU A;  2G9Y A;  3M8Z A;  2QZU A;  3IGY B;  1K7H A;  1ANI A;  1ELZ A;  1AJC A;  4FDI A;  3DYC A;  2GLQ A;  1N2K A;  1KH4 A;  3M7V A;  1N2L A;  1ALJ A;  3BDF A;  3T01 A;  1HDH A;  4FDJ A;  3ED4 A;  1KH9 A;  1EQJ A;  1ELY A;  1KHN A;  1ZEF A;  2GA3 A;  3M8W A;  3SZY A;  1EJJ A;  1Y6V A;  3TX0 A;  3BDH A;  3NVL A;  3TWZ A;  3T02 A;  1ZED A; 
#chains in the KnotProt database with same CATH topology
 1ALK A;  1ALI A;  1ANJ A;  1ELX A;  1AJD A;  3T00 A;  3IGZ B;  3BDG B;  1EW2 A;  3MK2 A;  1KH7 A;  1URA A;  3UN2 A;  1O99 A;  1KH5 A;  1HQA A;  1O98 A;  1ZEB A;  1EW8 A;  3MK1 A;  3MK0 A;  1E33 P;  3SZZ A;  1B8J A;  3UN5 A;  1SHQ A;  3BDG A;  3DPC A;  1E1Z P;  1AJA A;  2IFY A;  1EI6 A;  3M8Y A;  1ED9 A;  1KHJ A;  1URB A;  1Y7A A;  1P49 A;  3UO0 A;  1E3C P;  1SHN A;  1AJB A;  3UNY A;  1KHK A;  3OT9 A;  1AUK A;  1KHL A;  1EW9 A;  3UN3 A;  1ED8 A;  1HJK A;  2ANH A;  3CMR A;  1E2S P;  1FSU A;  2G9Y A;  3M8Z A;  2QZU A;  3IGY B;  1K7H A;  1ANI A;  1ELZ A;  1AJC A;  4FDI A;  3DYC A;  2GLQ A;  1N2K A;  1KH4 A;  3M7V A;  1N2L A;  1ALJ A;  3BDF A;  3T01 A;  1HDH A;  4FDJ A;  3ED4 A;  1KH9 A;  1EQJ A;  1ELY A;  1KHN A;  1ZEF A;  2GA3 A;  3M8W A;  3SZY A;  1EJJ A;  1Y6V A;  3TX0 A;  3BDH A;  3NVL A;  3TWZ A;  3T02 A;  1ZED A; 
#chains in the KnotProt database with same CATH homology
 1ALK A;  1ALI A;  1ANJ A;  1ELX A;  1AJD A;  3T00 A;  3IGZ B;  3BDG B;  1EW2 A;  3MK2 A;  1KH7 A;  1URA A;  3UN2 A;  1O99 A;  1KH5 A;  1HQA A;  1O98 A;  1ZEB A;  1EW8 A;  3MK1 A;  3MK0 A;  1E33 P;  3SZZ A;  1B8J A;  3UN5 A;  1SHQ A;  3BDG A;  3DPC A;  1E1Z P;  1AJA A;  2IFY A;  1EI6 A;  3M8Y A;  1ED9 A;  1KHJ A;  1URB A;  1Y7A A;  1P49 A;  3UO0 A;  1E3C P;  1SHN A;  1AJB A;  3UNY A;  1KHK A;  3OT9 A;  1AUK A;  1KHL A;  1EW9 A;  3UN3 A;  1ED8 A;  1HJK A;  2ANH A;  3CMR A;  1E2S P;  1FSU A;  2G9Y A;  3M8Z A;  2QZU A;  3IGY B;  1K7H A;  1ANI A;  1ELZ A;  1AJC A;  4FDI A;  3DYC A;  2GLQ A;  1N2K A;  1KH4 A;  3M7V A;  1N2L A;  1ALJ A;  3BDF A;  3T01 A;  1HDH A;  4FDJ A;  3ED4 A;  1KH9 A;  1EQJ A;  1ELY A;  1KHN A;  1ZEF A;  2GA3 A;  3M8W A;  3SZY A;  1EJJ A;  1Y6V A;  3TX0 A;  3BDH A;  3NVL A;  3TWZ A;  3T02 A;  1ZED A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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