3BDGA

Crystal structure of wild-type/t155v mixed dimer of e. coli alkaline phosphatase
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 159
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 46-367 322 1-45 418-448 368-417 45 31 slipknot
Chain Sequence
PEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDAVPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASI------ANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGHTGSQL--------RIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 46-365 320 1-45 396-434 366-395 45 39 slipknot
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3.1 46-395 350 1-45 402-434 396-401 45 33 slipknot
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2.1 44-401 358 1-43 406-434 402-405 43 29 slipknot
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2.1 37-405 369 1-5, 407-434 6-36, 406-406 5 28 slipknot
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2.1 31-359 329 1-7, 366-434 8-30, 360-365 7 69 slipknot
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2.1 38-360 323 1-30, 366-434 31-37, 361-365 30 69 slipknot
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2.1 39-361 323 1-37, 366-434 38-38, 362-365 37 69 slipknot
sequence length 448
structure length 434
publication title The Active-Site Trimetallic Cluster of Alkaline Phosphatase is Lost Upon Isosteric Mutation at the Mg2+-Coordinating Residue Threonine-155
rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
source organism Escherichia coli
missing residues 326-331, 403-410
total genus Genus: 159
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2007-11-14
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3bdgA00
2ANHA 3ED4A 3MK0A 1ALIA 1E33P 3T01A 3M8WA 1Y7AA 1N2KA 1EW2A 1EI6A 3M8YA 3BDFA 1EW8A 3SZZA 3T02A 1N2LA 1E2SP 1AJCA 1ELYA 1ZEDA 1AJAA 3M7VA 3BDGB 3MK1A 3T00A 1ANJA 1ELXA 1HQAA 3UO0A 3TWZA 3M8ZA 1ZEFA 1EW9A 2QZUA 1B8JA 4FDJA 1KH4A 3UN2A 1EQJA 3MK2A 2G9YA 2GLQA 1P49A 4FDIA 1ALKA 3UN5A 2GA3A 1O98A 2IFYA 3DYCA 1KH9A 1AUKA 3BDHA 1ZEBA 3TX0A 3CMRA 1E3CP 1ELZA 1E1ZP 1KHKA 1KHJA 1SHNA 1AJDA 3UNYA 1ALJA 1O99A 3DPCA 1ED8A 1ANIA 1Y6VA 1HJKA 3SZYA 1URBA 1SHQA 1KH5A 3IGZB 1KH7A 3UN3A 1KHLA 1EJJA 1HDHA 1FSUA 3OT9A 1KHNA 3IGYB 1ED9A 3NVLA 1K7HA 1URAA 3BDGA 1AJBA
chains in the KnotProt database with same CATH superfamily
2ANHA 3ED4A 3MK0A 1ALIA 1E33P 3T01A 3M8WA 1Y7AA 1N2KA 1EW2A 1EI6A 3M8YA 3BDFA 1EW8A 3SZZA 3T02A 1N2LA 1E2SP 1AJCA 1ELYA 1ZEDA 1AJAA 3M7VA 3BDGB 3MK1A 3T00A 1ANJA 1ELXA 1HQAA 3UO0A 3TWZA 3M8ZA 1ZEFA 1EW9A 2QZUA 1B8JA 4FDJA 1KH4A 3UN2A 1EQJA 3MK2A 2G9YA 2GLQA 1P49A 4FDIA 1ALKA 3UN5A 2GA3A 1O98A 2IFYA 3DYCA 1KH9A 1AUKA 3BDHA 1ZEBA 3TX0A 3CMRA 1E3CP 1ELZA 1E1ZP 1KHKA 1KHJA 1SHNA 1AJDA 3UNYA 1ALJA 1O99A 3DPCA 1ED8A 1ANIA 1Y6VA 1HJKA 3SZYA 1URBA 1SHQA 1KH5A 3IGZB 1KH7A 3UN3A 1KHLA 1EJJA 1HDHA 1FSUA 3OT9A 1KHNA 3IGYB 1ED9A 3NVLA 1K7HA 1URAA 3BDGA 1AJBA
chains in the KnotProt database with same CATH topology
2ANHA 3ED4A 3MK0A 1ALIA 1E33P 3T01A 3M8WA 1Y7AA 1N2KA 1EW2A 1EI6A 3M8YA 3BDFA 1EW8A 3SZZA 3T02A 1N2LA 1E2SP 1AJCA 1ELYA 1ZEDA 1AJAA 3M7VA 3BDGB 3MK1A 3T00A 1ANJA 1ELXA 1HQAA 3UO0A 3TWZA 3M8ZA 1ZEFA 1EW9A 2QZUA 1B8JA 4FDJA 1KH4A 3UN2A 1EQJA 3MK2A 2G9YA 2GLQA 1P49A 4FDIA 1ALKA 3UN5A 2GA3A 1O98A 2IFYA 3DYCA 1KH9A 1AUKA 3BDHA 1ZEBA 3TX0A 3CMRA 1E3CP 1ELZA 1E1ZP 1KHKA 1KHJA 1SHNA 1AJDA 3UNYA 1ALJA 1O99A 3DPCA 1ED8A 1ANIA 1Y6VA 1HJKA 3SZYA 1URBA 1SHQA 1KH5A 3IGZB 1KH7A 3UN3A 1KHLA 1EJJA 1HDHA 1FSUA 3OT9A 1KHNA 3IGYB 1ED9A 3NVLA 1K7HA 1URAA 3BDGA 1AJBA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 2ANH A;  3ED4 A;  3MK0 A;  1ALI A;  1E33 P;  3T01 A;  3M8W A;  1Y7A A;  1N2K A;  1EW2 A;  1EI6 A;  3M8Y A;  3BDF A;  1EW8 A;  3SZZ A;  3T02 A;  1N2L A;  1E2S P;  1AJC A;  1ELY A;  1ZED A;  1AJA A;  3M7V A;  3BDG B;  3MK1 A;  3T00 A;  1ANJ A;  1ELX A;  1HQA A;  3UO0 A;  3TWZ A;  3M8Z A;  1ZEF A;  1EW9 A;  2QZU A;  1B8J A;  4FDJ A;  1KH4 A;  3UN2 A;  1EQJ A;  3MK2 A;  2G9Y A;  2GLQ A;  1P49 A;  4FDI A;  1ALK A;  3UN5 A;  2GA3 A;  1O98 A;  2IFY A;  3DYC A;  1KH9 A;  1AUK A;  3BDH A;  1ZEB A;  3TX0 A;  3CMR A;  1E3C P;  1ELZ A;  1E1Z P;  1KHK A;  1KHJ A;  1SHN A;  1AJD A;  3UNY A;  1ALJ A;  1O99 A;  3DPC A;  1ED8 A;  1ANI A;  1Y6V A;  1HJK A;  3SZY A;  1URB A;  1SHQ A;  1KH5 A;  3IGZ B;  1KH7 A;  3UN3 A;  1KHL A;  1EJJ A;  1HDH A;  1FSU A;  3OT9 A;  1KHN A;  3IGY B;  1ED9 A;  3NVL A;  1K7H A;  1URA A;  3BDG A;  1AJB A; 
#chains in the KnotProt database with same CATH topology
 2ANH A;  3ED4 A;  3MK0 A;  1ALI A;  1E33 P;  3T01 A;  3M8W A;  1Y7A A;  1N2K A;  1EW2 A;  1EI6 A;  3M8Y A;  3BDF A;  1EW8 A;  3SZZ A;  3T02 A;  1N2L A;  1E2S P;  1AJC A;  1ELY A;  1ZED A;  1AJA A;  3M7V A;  3BDG B;  3MK1 A;  3T00 A;  1ANJ A;  1ELX A;  1HQA A;  3UO0 A;  3TWZ A;  3M8Z A;  1ZEF A;  1EW9 A;  2QZU A;  1B8J A;  4FDJ A;  1KH4 A;  3UN2 A;  1EQJ A;  3MK2 A;  2G9Y A;  2GLQ A;  1P49 A;  4FDI A;  1ALK A;  3UN5 A;  2GA3 A;  1O98 A;  2IFY A;  3DYC A;  1KH9 A;  1AUK A;  3BDH A;  1ZEB A;  3TX0 A;  3CMR A;  1E3C P;  1ELZ A;  1E1Z P;  1KHK A;  1KHJ A;  1SHN A;  1AJD A;  3UNY A;  1ALJ A;  1O99 A;  3DPC A;  1ED8 A;  1ANI A;  1Y6V A;  1HJK A;  3SZY A;  1URB A;  1SHQ A;  1KH5 A;  3IGZ B;  1KH7 A;  3UN3 A;  1KHL A;  1EJJ A;  1HDH A;  1FSU A;  3OT9 A;  1KHN A;  3IGY B;  1ED9 A;  3NVL A;  1K7H A;  1URA A;  3BDG A;  1AJB A; 
#chains in the KnotProt database with same CATH homology
 2ANH A;  3ED4 A;  3MK0 A;  1ALI A;  1E33 P;  3T01 A;  3M8W A;  1Y7A A;  1N2K A;  1EW2 A;  1EI6 A;  3M8Y A;  3BDF A;  1EW8 A;  3SZZ A;  3T02 A;  1N2L A;  1E2S P;  1AJC A;  1ELY A;  1ZED A;  1AJA A;  3M7V A;  3BDG B;  3MK1 A;  3T00 A;  1ANJ A;  1ELX A;  1HQA A;  3UO0 A;  3TWZ A;  3M8Z A;  1ZEF A;  1EW9 A;  2QZU A;  1B8J A;  4FDJ A;  1KH4 A;  3UN2 A;  1EQJ A;  3MK2 A;  2G9Y A;  2GLQ A;  1P49 A;  4FDI A;  1ALK A;  3UN5 A;  2GA3 A;  1O98 A;  2IFY A;  3DYC A;  1KH9 A;  1AUK A;  3BDH A;  1ZEB A;  3TX0 A;  3CMR A;  1E3C P;  1ELZ A;  1E1Z P;  1KHK A;  1KHJ A;  1SHN A;  1AJD A;  3UNY A;  1ALJ A;  1O99 A;  3DPC A;  1ED8 A;  1ANI A;  1Y6V A;  1HJK A;  3SZY A;  1URB A;  1SHQ A;  1KH5 A;  3IGZ B;  1KH7 A;  3UN3 A;  1KHL A;  1EJJ A;  1HDH A;  1FSU A;  3OT9 A;  1KHN A;  3IGY B;  1ED9 A;  3NVL A;  1K7H A;  1URA A;  3BDG A;  1AJB A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling