3BDGA

Crystal structure of wild-type/t155v mixed dimer of e. coli alkaline phosphatase
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 159
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 46-367 322 1-45 418-448 368-417 45 31 slipknot
Chain Sequence
PEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDAVPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASI------ANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGHTGSQL--------RIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 46-365 320 1-45 396-434 366-395 45 39 slipknot
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3.1 46-395 350 1-45 402-434 396-401 45 33 slipknot
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2.1 44-401 358 1-43 406-434 402-405 43 29 slipknot
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2.1 37-405 369 1-5, 407-434 6-36, 406-406 5 28 slipknot
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2.1 31-359 329 1-7, 366-434 8-30, 360-365 7 69 slipknot
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2.1 38-360 323 1-30, 366-434 31-37, 361-365 30 69 slipknot
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2.1 39-361 323 1-37, 366-434 38-38, 362-365 37 69 slipknot
sequence length 448
structure length 434
publication title The Active-Site Trimetallic Cluster of Alkaline Phosphatase is Lost Upon Isosteric Mutation at the Mg2+-Coordinating Residue Threonine-155
rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
source organism Escherichia coli
missing residues 326-331, 403-410
total genus Genus: 159
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2007-11-14
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3bdgA00
3ED4A 4FDIA 2ANHA 3DYCA 3CMRA 1ALKA 1ZEDA 1ANJA 1KHJA 3IGYB 1E33P 1KH4A 1O98A 1EW2A 3M7VA 1E1ZP 3BDGA 1N2KA 1URBA 1K7HA 2GLQA 1FSUA 3M8WA 1O99A 3OT9A 3UN2A 1B8JA 1ALIA 1Y7AA 1KH9A 3DPCA 1HJKA 1HQAA 1P49A 3M8YA 1KH7A 1ZEBA 1URAA 1E3CP 3UN3A 1EJJA 1ED9A 1AJDA 3BDGB 3SZYA 3MK1A 3T02A 1ELXA 1AJAA 1Y6VA 3UO0A 3BDHA 3T00A 2G9YA 2QZUA 3TWZA 1ANIA 1AUKA 1N2LA 1AJBA 3BDFA 3M8ZA 1E2SP 1ELZA 1SHNA 1HDHA 4FDJA 1KHKA 3MK2A 3MK0A 1ED8A 3IGZB 1ELYA 3UN5A 1ZEFA 1EI6A 2IFYA 1EW9A 1KHLA 3T01A 2GA3A 1EQJA 3UNYA 3SZZA 1ALJA 1EW8A 1SHQA 3NVLA 1KH5A 1KHNA 1AJCA 3TX0A
chains in the KnotProt database with same CATH superfamily
3ED4A 4FDIA 2ANHA 3DYCA 3CMRA 1ALKA 1ZEDA 1ANJA 1KHJA 3IGYB 1E33P 1KH4A 1O98A 1EW2A 3M7VA 1E1ZP 3BDGA 1N2KA 1URBA 1K7HA 2GLQA 1FSUA 3M8WA 1O99A 3OT9A 3UN2A 1B8JA 1ALIA 1Y7AA 1KH9A 3DPCA 1HJKA 1HQAA 1P49A 3M8YA 1KH7A 1ZEBA 1URAA 1E3CP 3UN3A 1EJJA 1ED9A 1AJDA 3BDGB 3SZYA 3MK1A 3T02A 1ELXA 1AJAA 1Y6VA 3UO0A 3BDHA 3T00A 2G9YA 2QZUA 3TWZA 1ANIA 1AUKA 1N2LA 1AJBA 3BDFA 3M8ZA 1E2SP 1ELZA 1SHNA 1HDHA 4FDJA 1KHKA 3MK2A 3MK0A 1ED8A 3IGZB 1ELYA 3UN5A 1ZEFA 1EI6A 2IFYA 1EW9A 1KHLA 3T01A 2GA3A 1EQJA 3UNYA 3SZZA 1ALJA 1EW8A 1SHQA 3NVLA 1KH5A 1KHNA 1AJCA 3TX0A
chains in the KnotProt database with same CATH topology
3ED4A 4FDIA 2ANHA 3DYCA 3CMRA 1ALKA 1ZEDA 1ANJA 1KHJA 3IGYB 1E33P 1KH4A 1O98A 1EW2A 3M7VA 1E1ZP 3BDGA 1N2KA 1URBA 1K7HA 2GLQA 1FSUA 3M8WA 1O99A 3OT9A 3UN2A 1B8JA 1ALIA 1Y7AA 1KH9A 3DPCA 1HJKA 1HQAA 1P49A 3M8YA 1KH7A 1ZEBA 1URAA 1E3CP 3UN3A 1EJJA 1ED9A 1AJDA 3BDGB 3SZYA 3MK1A 3T02A 1ELXA 1AJAA 1Y6VA 3UO0A 3BDHA 3T00A 2G9YA 2QZUA 3TWZA 1ANIA 1AUKA 1N2LA 1AJBA 3BDFA 3M8ZA 1E2SP 1ELZA 1SHNA 1HDHA 4FDJA 1KHKA 3MK2A 3MK0A 1ED8A 3IGZB 1ELYA 3UN5A 1ZEFA 1EI6A 2IFYA 1EW9A 1KHLA 3T01A 2GA3A 1EQJA 3UNYA 3SZZA 1ALJA 1EW8A 1SHQA 3NVLA 1KH5A 1KHNA 1AJCA 3TX0A
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 3ED4 A;  4FDI A;  2ANH A;  3DYC A;  3CMR A;  1ALK A;  1ZED A;  1ANJ A;  1KHJ A;  3IGY B;  1E33 P;  1KH4 A;  1O98 A;  1EW2 A;  3M7V A;  1E1Z P;  3BDG A;  1N2K A;  1URB A;  1K7H A;  2GLQ A;  1FSU A;  3M8W A;  1O99 A;  3OT9 A;  3UN2 A;  1B8J A;  1ALI A;  1Y7A A;  1KH9 A;  3DPC A;  1HJK A;  1HQA A;  1P49 A;  3M8Y A;  1KH7 A;  1ZEB A;  1URA A;  1E3C P;  3UN3 A;  1EJJ A;  1ED9 A;  1AJD A;  3BDG B;  3SZY A;  3MK1 A;  3T02 A;  1ELX A;  1AJA A;  1Y6V A;  3UO0 A;  3BDH A;  3T00 A;  2G9Y A;  2QZU A;  3TWZ A;  1ANI A;  1AUK A;  1N2L A;  1AJB A;  3BDF A;  3M8Z A;  1E2S P;  1ELZ A;  1SHN A;  1HDH A;  4FDJ A;  1KHK A;  3MK2 A;  3MK0 A;  1ED8 A;  3IGZ B;  1ELY A;  3UN5 A;  1ZEF A;  1EI6 A;  2IFY A;  1EW9 A;  1KHL A;  3T01 A;  2GA3 A;  1EQJ A;  3UNY A;  3SZZ A;  1ALJ A;  1EW8 A;  1SHQ A;  3NVL A;  1KH5 A;  1KHN A;  1AJC A;  3TX0 A; 
#chains in the KnotProt database with same CATH topology
 3ED4 A;  4FDI A;  2ANH A;  3DYC A;  3CMR A;  1ALK A;  1ZED A;  1ANJ A;  1KHJ A;  3IGY B;  1E33 P;  1KH4 A;  1O98 A;  1EW2 A;  3M7V A;  1E1Z P;  3BDG A;  1N2K A;  1URB A;  1K7H A;  2GLQ A;  1FSU A;  3M8W A;  1O99 A;  3OT9 A;  3UN2 A;  1B8J A;  1ALI A;  1Y7A A;  1KH9 A;  3DPC A;  1HJK A;  1HQA A;  1P49 A;  3M8Y A;  1KH7 A;  1ZEB A;  1URA A;  1E3C P;  3UN3 A;  1EJJ A;  1ED9 A;  1AJD A;  3BDG B;  3SZY A;  3MK1 A;  3T02 A;  1ELX A;  1AJA A;  1Y6V A;  3UO0 A;  3BDH A;  3T00 A;  2G9Y A;  2QZU A;  3TWZ A;  1ANI A;  1AUK A;  1N2L A;  1AJB A;  3BDF A;  3M8Z A;  1E2S P;  1ELZ A;  1SHN A;  1HDH A;  4FDJ A;  1KHK A;  3MK2 A;  3MK0 A;  1ED8 A;  3IGZ B;  1ELY A;  3UN5 A;  1ZEF A;  1EI6 A;  2IFY A;  1EW9 A;  1KHL A;  3T01 A;  2GA3 A;  1EQJ A;  3UNY A;  3SZZ A;  1ALJ A;  1EW8 A;  1SHQ A;  3NVL A;  1KH5 A;  1KHN A;  1AJC A;  3TX0 A; 
#chains in the KnotProt database with same CATH homology
 3ED4 A;  4FDI A;  2ANH A;  3DYC A;  3CMR A;  1ALK A;  1ZED A;  1ANJ A;  1KHJ A;  3IGY B;  1E33 P;  1KH4 A;  1O98 A;  1EW2 A;  3M7V A;  1E1Z P;  3BDG A;  1N2K A;  1URB A;  1K7H A;  2GLQ A;  1FSU A;  3M8W A;  1O99 A;  3OT9 A;  3UN2 A;  1B8J A;  1ALI A;  1Y7A A;  1KH9 A;  3DPC A;  1HJK A;  1HQA A;  1P49 A;  3M8Y A;  1KH7 A;  1ZEB A;  1URA A;  1E3C P;  3UN3 A;  1EJJ A;  1ED9 A;  1AJD A;  3BDG B;  3SZY A;  3MK1 A;  3T02 A;  1ELX A;  1AJA A;  1Y6V A;  3UO0 A;  3BDH A;  3T00 A;  2G9Y A;  2QZU A;  3TWZ A;  1ANI A;  1AUK A;  1N2L A;  1AJB A;  3BDF A;  3M8Z A;  1E2S P;  1ELZ A;  1SHN A;  1HDH A;  4FDJ A;  1KHK A;  3MK2 A;  3MK0 A;  1ED8 A;  3IGZ B;  1ELY A;  3UN5 A;  1ZEF A;  1EI6 A;  2IFY A;  1EW9 A;  1KHL A;  3T01 A;  2GA3 A;  1EQJ A;  3UNY A;  3SZZ A;  1ALJ A;  1EW8 A;  1SHQ A;  3NVL A;  1KH5 A;  1KHN A;  1AJC A;  3TX0 A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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