3BDGB

Crystal structure of wild-type/t155v mixed dimer of e. coli alkaline phosphatase
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 159
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 43-365 323 1-42 416-446 366-415 42 31 slipknot
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASI-----AANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGHTGSQ--------LRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 45-361 317 1-44 400-433 362-399 44 34 slipknot
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3.1 42-399 358 1-41 403-433 400-402 41 31 slipknot
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2.1 41-402 362 1-40 405-433 403-404 40 29 slipknot
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2.1 31-359 329 1-17, 362-433 18-30, 360-361 17 72 slipknot
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2.1 36-359 324 1-30, 362-433 31-35, 360-361 30 72 slipknot
sequence length 446
structure length 433
publication title The Active-Site Trimetallic Cluster of Alkaline Phosphatase is Lost Upon Isosteric Mutation at the Mg2+-Coordinating Residue Threonine-155
rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
source organism Escherichia coli
missing residues 324-328, 401-408
total genus Genus: 159
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2007-11-14
KnotProt deposition date 2014-10-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00245 Alk_phosphatase Alkaline phosphatase
B PF00245.15 Alk_phosphatase Alkaline phosphatase
B PF00245.15 Alk_phosphatase Alkaline phosphatase
B PF01663.17 Phosphodiest Type I phosphodiesterase / nucleotide pyrophosphatase
B PF01676.13 Metalloenzyme Metalloenzyme superfamily
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3bdgB00
3SZYA 1E3CP 1ELYA 3SZZA 2GLQA 1KHLA 3M8YA 3T01A 1N2KA 1ZEFA 1AJCA 1AJAA 1E33P 1HQAA 1ED9A 1HDHA 1KH4A 1AJBA 1N2LA 1HJKA 1ALIA 2G9YA 1Y6VA 3BDGA 1EW8A 1KHNA 3CMRA 1P49A 3M8WA 1KH9A 1URBA 1SHQA 3BDFA 1B8JA 1EQJA 3UNYA 2ANHA 1EJJA 3UN3A 1EI6A 3BDGB 1AJDA 3MK2A 1ELXA 3MK0A 1K7HA 1ALJA 3IGYB 1ANIA 3MK1A 3TX0A 1E2SP 1ALKA 3UO0A 1ZEBA 1AUKA 2GA3A 1KH5A 1E1ZP 2QZUA 1EW9A 1SHNA 4FDIA 3UN5A 1URAA 1FSUA 3DPCA 3NVLA 1KH7A 1ELZA 3M7VA 3ED4A 3DYCA 1ED8A 2IFYA 3OT9A 1O98A 4FDJA 3BDHA 3M8ZA 3TWZA 3T00A 1ZEDA 1O99A 1KHKA 3T02A 3IGZB 1EW2A 1ANJA 1KHJA 3UN2A 1Y7AA
chains in the KnotProt database with same CATH superfamily
3SZYA 1E3CP 1ELYA 3SZZA 2GLQA 1KHLA 3M8YA 3T01A 1N2KA 1ZEFA 1AJCA 1AJAA 1E33P 1HQAA 1ED9A 1HDHA 1KH4A 1AJBA 1N2LA 1HJKA 1ALIA 2G9YA 1Y6VA 3BDGA 1EW8A 1KHNA 3CMRA 1P49A 3M8WA 1KH9A 1URBA 1SHQA 3BDFA 1B8JA 1EQJA 3UNYA 2ANHA 1EJJA 3UN3A 1EI6A 3BDGB 1AJDA 3MK2A 1ELXA 3MK0A 1K7HA 1ALJA 3IGYB 1ANIA 3MK1A 3TX0A 1E2SP 1ALKA 3UO0A 1ZEBA 1AUKA 2GA3A 1KH5A 1E1ZP 2QZUA 1EW9A 1SHNA 4FDIA 3UN5A 1URAA 1FSUA 3DPCA 3NVLA 1KH7A 1ELZA 3M7VA 3ED4A 3DYCA 1ED8A 2IFYA 3OT9A 1O98A 4FDJA 3BDHA 3M8ZA 3TWZA 3T00A 1ZEDA 1O99A 1KHKA 3T02A 3IGZB 1EW2A 1ANJA 1KHJA 3UN2A 1Y7AA
chains in the KnotProt database with same CATH topology
3SZYA 1E3CP 1ELYA 3SZZA 2GLQA 1KHLA 3M8YA 3T01A 1N2KA 1ZEFA 1AJCA 1AJAA 1E33P 1HQAA 1ED9A 1HDHA 1KH4A 1AJBA 1N2LA 1HJKA 1ALIA 2G9YA 1Y6VA 3BDGA 1EW8A 1KHNA 3CMRA 1P49A 3M8WA 1KH9A 1URBA 1SHQA 3BDFA 1B8JA 1EQJA 3UNYA 2ANHA 1EJJA 3UN3A 1EI6A 3BDGB 1AJDA 3MK2A 1ELXA 3MK0A 1K7HA 1ALJA 3IGYB 1ANIA 3MK1A 3TX0A 1E2SP 1ALKA 3UO0A 1ZEBA 1AUKA 2GA3A 1KH5A 1E1ZP 2QZUA 1EW9A 1SHNA 4FDIA 3UN5A 1URAA 1FSUA 3DPCA 3NVLA 1KH7A 1ELZA 3M7VA 3ED4A 3DYCA 1ED8A 2IFYA 3OT9A 1O98A 4FDJA 3BDHA 3M8ZA 3TWZA 3T00A 1ZEDA 1O99A 1KHKA 3T02A 3IGZB 1EW2A 1ANJA 1KHJA 3UN2A 1Y7AA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 3SZY A;  1E3C P;  1ELY A;  3SZZ A;  2GLQ A;  1KHL A;  3M8Y A;  3T01 A;  1N2K A;  1ZEF A;  1AJC A;  1AJA A;  1E33 P;  1HQA A;  1ED9 A;  1HDH A;  1KH4 A;  1AJB A;  1N2L A;  1HJK A;  1ALI A;  2G9Y A;  1Y6V A;  3BDG A;  1EW8 A;  1KHN A;  3CMR A;  1P49 A;  3M8W A;  1KH9 A;  1URB A;  1SHQ A;  3BDF A;  1B8J A;  1EQJ A;  3UNY A;  2ANH A;  1EJJ A;  3UN3 A;  1EI6 A;  3BDG B;  1AJD A;  3MK2 A;  1ELX A;  3MK0 A;  1K7H A;  1ALJ A;  3IGY B;  1ANI A;  3MK1 A;  3TX0 A;  1E2S P;  1ALK A;  3UO0 A;  1ZEB A;  1AUK A;  2GA3 A;  1KH5 A;  1E1Z P;  2QZU A;  1EW9 A;  1SHN A;  4FDI A;  3UN5 A;  1URA A;  1FSU A;  3DPC A;  3NVL A;  1KH7 A;  1ELZ A;  3M7V A;  3ED4 A;  3DYC A;  1ED8 A;  2IFY A;  3OT9 A;  1O98 A;  4FDJ A;  3BDH A;  3M8Z A;  3TWZ A;  3T00 A;  1ZED A;  1O99 A;  1KHK A;  3T02 A;  3IGZ B;  1EW2 A;  1ANJ A;  1KHJ A;  3UN2 A;  1Y7A A; 
#chains in the KnotProt database with same CATH topology
 3SZY A;  1E3C P;  1ELY A;  3SZZ A;  2GLQ A;  1KHL A;  3M8Y A;  3T01 A;  1N2K A;  1ZEF A;  1AJC A;  1AJA A;  1E33 P;  1HQA A;  1ED9 A;  1HDH A;  1KH4 A;  1AJB A;  1N2L A;  1HJK A;  1ALI A;  2G9Y A;  1Y6V A;  3BDG A;  1EW8 A;  1KHN A;  3CMR A;  1P49 A;  3M8W A;  1KH9 A;  1URB A;  1SHQ A;  3BDF A;  1B8J A;  1EQJ A;  3UNY A;  2ANH A;  1EJJ A;  3UN3 A;  1EI6 A;  3BDG B;  1AJD A;  3MK2 A;  1ELX A;  3MK0 A;  1K7H A;  1ALJ A;  3IGY B;  1ANI A;  3MK1 A;  3TX0 A;  1E2S P;  1ALK A;  3UO0 A;  1ZEB A;  1AUK A;  2GA3 A;  1KH5 A;  1E1Z P;  2QZU A;  1EW9 A;  1SHN A;  4FDI A;  3UN5 A;  1URA A;  1FSU A;  3DPC A;  3NVL A;  1KH7 A;  1ELZ A;  3M7V A;  3ED4 A;  3DYC A;  1ED8 A;  2IFY A;  3OT9 A;  1O98 A;  4FDJ A;  3BDH A;  3M8Z A;  3TWZ A;  3T00 A;  1ZED A;  1O99 A;  1KHK A;  3T02 A;  3IGZ B;  1EW2 A;  1ANJ A;  1KHJ A;  3UN2 A;  1Y7A A; 
#chains in the KnotProt database with same CATH homology
 3SZY A;  1E3C P;  1ELY A;  3SZZ A;  2GLQ A;  1KHL A;  3M8Y A;  3T01 A;  1N2K A;  1ZEF A;  1AJC A;  1AJA A;  1E33 P;  1HQA A;  1ED9 A;  1HDH A;  1KH4 A;  1AJB A;  1N2L A;  1HJK A;  1ALI A;  2G9Y A;  1Y6V A;  3BDG A;  1EW8 A;  1KHN A;  3CMR A;  1P49 A;  3M8W A;  1KH9 A;  1URB A;  1SHQ A;  3BDF A;  1B8J A;  1EQJ A;  3UNY A;  2ANH A;  1EJJ A;  3UN3 A;  1EI6 A;  3BDG B;  1AJD A;  3MK2 A;  1ELX A;  3MK0 A;  1K7H A;  1ALJ A;  3IGY B;  1ANI A;  3MK1 A;  3TX0 A;  1E2S P;  1ALK A;  3UO0 A;  1ZEB A;  1AUK A;  2GA3 A;  1KH5 A;  1E1Z P;  2QZU A;  1EW9 A;  1SHN A;  4FDI A;  3UN5 A;  1URA A;  1FSU A;  3DPC A;  3NVL A;  1KH7 A;  1ELZ A;  3M7V A;  3ED4 A;  3DYC A;  1ED8 A;  2IFY A;  3OT9 A;  1O98 A;  4FDJ A;  3BDH A;  3M8Z A;  3TWZ A;  3T00 A;  1ZED A;  1O99 A;  1KHK A;  3T02 A;  3IGZ B;  1EW2 A;  1ANJ A;  1KHJ A;  3UN2 A;  1Y7A A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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