3BDGB

Crystal structure of wild-type/t155v mixed dimer of e. coli alkaline phosphatase
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 159
Slipknot S +31

  Help Knotting data interpretation Full screen
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 43-365 323 1-42 416-446 366-415 42 31 slipknot
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASI-----AANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGHTGSQ--------LRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis

  Help Knotoid data interpretation Full screen
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


  Help Knotoid subchains data interpretation Full screen
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 45-361 317 1-44 400-433 362-399 44 34 slipknot
view details
3.1 42-399 358 1-41 403-433 400-402 41 31 slipknot
view details
2.1 41-402 362 1-40 405-433 403-404 40 29 slipknot
view details
2.1 31-359 329 1-17, 362-433 18-30, 360-361 17 72 slipknot
view details
2.1 36-359 324 1-30, 362-433 31-35, 360-361 30 72 slipknot
sequence length 446
structure length 433
publication title The Active-Site Trimetallic Cluster of Alkaline Phosphatase is Lost Upon Isosteric Mutation at the Mg2+-Coordinating Residue Threonine-155
rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
source organism Escherichia coli
missing residues 324-328, 401-408
total genus Genus: 159
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2007-11-14
KnotProt deposition date 2014-10-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00245 Alk_phosphatase Alkaline phosphatase
B PF00245.15 Alk_phosphatase Alkaline phosphatase
B PF00245.15 Alk_phosphatase Alkaline phosphatase
B PF01663.17 Phosphodiest Type I phosphodiesterase / nucleotide pyrophosphatase
B PF01676.13 Metalloenzyme Metalloenzyme superfamily
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3bdgB00
3MK0A 2ANHA 3UO0A 1ALJA 1AJCA 1ED9A 3UN5A 3T02A 1ELZA 3T00A 1AUKA 1N2KA 3MK2A 3DYCA 3IGZB 1N2LA 1Y6VA 1EJJA 1ELYA 1HJKA 3M8YA 1E33P 3ED4A 3SZYA 2GA3A 1HDHA 1KHJA 1EW9A 2G9YA 1KH5A 3T01A 3TWZA 1E1ZP 1E3CP 1SHQA 1ZEBA 3SZZA 1ZEDA 1AJAA 1K7HA 1B8JA 3M7VA 3BDGB 2GLQA 1AJDA 4FDJA 1P49A 1O99A 3M8WA 3M8ZA 1EI6A 3UN3A 1KH9A 1KHKA 1KHLA 1Y7AA 3TX0A 2QZUA 1EW2A 1URAA 4FDIA 1EW8A 3DPCA 3UN2A 1ZEFA 3UNYA 1ANJA 1ALKA 1KHNA 3BDFA 1HQAA 1E2SP 1ELXA 1URBA 3BDGA 1O98A 1SHNA 1ALIA 3OT9A 3NVLA 1KH7A 1FSUA 3IGYB 1ANIA 3BDHA 3MK1A 1AJBA 1EQJA 1KH4A 1ED8A 3CMRA 2IFYA
chains in the KnotProt database with same CATH superfamily
3MK0A 2ANHA 3UO0A 1ALJA 1AJCA 1ED9A 3UN5A 3T02A 1ELZA 3T00A 1AUKA 1N2KA 3MK2A 3DYCA 3IGZB 1N2LA 1Y6VA 1EJJA 1ELYA 1HJKA 3M8YA 1E33P 3ED4A 3SZYA 2GA3A 1HDHA 1KHJA 1EW9A 2G9YA 1KH5A 3T01A 3TWZA 1E1ZP 1E3CP 1SHQA 1ZEBA 3SZZA 1ZEDA 1AJAA 1K7HA 1B8JA 3M7VA 3BDGB 2GLQA 1AJDA 4FDJA 1P49A 1O99A 3M8WA 3M8ZA 1EI6A 3UN3A 1KH9A 1KHKA 1KHLA 1Y7AA 3TX0A 2QZUA 1EW2A 1URAA 4FDIA 1EW8A 3DPCA 3UN2A 1ZEFA 3UNYA 1ANJA 1ALKA 1KHNA 3BDFA 1HQAA 1E2SP 1ELXA 1URBA 3BDGA 1O98A 1SHNA 1ALIA 3OT9A 3NVLA 1KH7A 1FSUA 3IGYB 1ANIA 3BDHA 3MK1A 1AJBA 1EQJA 1KH4A 1ED8A 3CMRA 2IFYA
chains in the KnotProt database with same CATH topology
3MK0A 2ANHA 3UO0A 1ALJA 1AJCA 1ED9A 3UN5A 3T02A 1ELZA 3T00A 1AUKA 1N2KA 3MK2A 3DYCA 3IGZB 1N2LA 1Y6VA 1EJJA 1ELYA 1HJKA 3M8YA 1E33P 3ED4A 3SZYA 2GA3A 1HDHA 1KHJA 1EW9A 2G9YA 1KH5A 3T01A 3TWZA 1E1ZP 1E3CP 1SHQA 1ZEBA 3SZZA 1ZEDA 1AJAA 1K7HA 1B8JA 3M7VA 3BDGB 2GLQA 1AJDA 4FDJA 1P49A 1O99A 3M8WA 3M8ZA 1EI6A 3UN3A 1KH9A 1KHKA 1KHLA 1Y7AA 3TX0A 2QZUA 1EW2A 1URAA 4FDIA 1EW8A 3DPCA 3UN2A 1ZEFA 3UNYA 1ANJA 1ALKA 1KHNA 3BDFA 1HQAA 1E2SP 1ELXA 1URBA 3BDGA 1O98A 1SHNA 1ALIA 3OT9A 3NVLA 1KH7A 1FSUA 3IGYB 1ANIA 3BDHA 3MK1A 1AJBA 1EQJA 1KH4A 1ED8A 3CMRA 2IFYA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 3MK0 A;  2ANH A;  3UO0 A;  1ALJ A;  1AJC A;  1ED9 A;  3UN5 A;  3T02 A;  1ELZ A;  3T00 A;  1AUK A;  1N2K A;  3MK2 A;  3DYC A;  3IGZ B;  1N2L A;  1Y6V A;  1EJJ A;  1ELY A;  1HJK A;  3M8Y A;  1E33 P;  3ED4 A;  3SZY A;  2GA3 A;  1HDH A;  1KHJ A;  1EW9 A;  2G9Y A;  1KH5 A;  3T01 A;  3TWZ A;  1E1Z P;  1E3C P;  1SHQ A;  1ZEB A;  3SZZ A;  1ZED A;  1AJA A;  1K7H A;  1B8J A;  3M7V A;  3BDG B;  2GLQ A;  1AJD A;  4FDJ A;  1P49 A;  1O99 A;  3M8W A;  3M8Z A;  1EI6 A;  3UN3 A;  1KH9 A;  1KHK A;  1KHL A;  1Y7A A;  3TX0 A;  2QZU A;  1EW2 A;  1URA A;  4FDI A;  1EW8 A;  3DPC A;  3UN2 A;  1ZEF A;  3UNY A;  1ANJ A;  1ALK A;  1KHN A;  3BDF A;  1HQA A;  1E2S P;  1ELX A;  1URB A;  3BDG A;  1O98 A;  1SHN A;  1ALI A;  3OT9 A;  3NVL A;  1KH7 A;  1FSU A;  3IGY B;  1ANI A;  3BDH A;  3MK1 A;  1AJB A;  1EQJ A;  1KH4 A;  1ED8 A;  3CMR A;  2IFY A; 
#chains in the KnotProt database with same CATH topology
 3MK0 A;  2ANH A;  3UO0 A;  1ALJ A;  1AJC A;  1ED9 A;  3UN5 A;  3T02 A;  1ELZ A;  3T00 A;  1AUK A;  1N2K A;  3MK2 A;  3DYC A;  3IGZ B;  1N2L A;  1Y6V A;  1EJJ A;  1ELY A;  1HJK A;  3M8Y A;  1E33 P;  3ED4 A;  3SZY A;  2GA3 A;  1HDH A;  1KHJ A;  1EW9 A;  2G9Y A;  1KH5 A;  3T01 A;  3TWZ A;  1E1Z P;  1E3C P;  1SHQ A;  1ZEB A;  3SZZ A;  1ZED A;  1AJA A;  1K7H A;  1B8J A;  3M7V A;  3BDG B;  2GLQ A;  1AJD A;  4FDJ A;  1P49 A;  1O99 A;  3M8W A;  3M8Z A;  1EI6 A;  3UN3 A;  1KH9 A;  1KHK A;  1KHL A;  1Y7A A;  3TX0 A;  2QZU A;  1EW2 A;  1URA A;  4FDI A;  1EW8 A;  3DPC A;  3UN2 A;  1ZEF A;  3UNY A;  1ANJ A;  1ALK A;  1KHN A;  3BDF A;  1HQA A;  1E2S P;  1ELX A;  1URB A;  3BDG A;  1O98 A;  1SHN A;  1ALI A;  3OT9 A;  3NVL A;  1KH7 A;  1FSU A;  3IGY B;  1ANI A;  3BDH A;  3MK1 A;  1AJB A;  1EQJ A;  1KH4 A;  1ED8 A;  3CMR A;  2IFY A; 
#chains in the KnotProt database with same CATH homology
 3MK0 A;  2ANH A;  3UO0 A;  1ALJ A;  1AJC A;  1ED9 A;  3UN5 A;  3T02 A;  1ELZ A;  3T00 A;  1AUK A;  1N2K A;  3MK2 A;  3DYC A;  3IGZ B;  1N2L A;  1Y6V A;  1EJJ A;  1ELY A;  1HJK A;  3M8Y A;  1E33 P;  3ED4 A;  3SZY A;  2GA3 A;  1HDH A;  1KHJ A;  1EW9 A;  2G9Y A;  1KH5 A;  3T01 A;  3TWZ A;  1E1Z P;  1E3C P;  1SHQ A;  1ZEB A;  3SZZ A;  1ZED A;  1AJA A;  1K7H A;  1B8J A;  3M7V A;  3BDG B;  2GLQ A;  1AJD A;  4FDJ A;  1P49 A;  1O99 A;  3M8W A;  3M8Z A;  1EI6 A;  3UN3 A;  1KH9 A;  1KHK A;  1KHL A;  1Y7A A;  3TX0 A;  2QZU A;  1EW2 A;  1URA A;  4FDI A;  1EW8 A;  3DPC A;  3UN2 A;  1ZEF A;  3UNY A;  1ANJ A;  1ALK A;  1KHN A;  3BDF A;  1HQA A;  1E2S P;  1ELX A;  1URB A;  3BDG A;  1O98 A;  1SHN A;  1ALI A;  3OT9 A;  3NVL A;  1KH7 A;  1FSU A;  3IGY B;  1ANI A;  3BDH A;  3MK1 A;  1AJB A;  1EQJ A;  1KH4 A;  1ED8 A;  3CMR A;  2IFY A;
...loading similar chains, please wait...
similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...
How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling