3BDGB

Crystal structure of wild-type/t155v mixed dimer of e. coli alkaline phosphatase
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 159
Slipknot S +31

  Help Knotting data interpretation Full screen
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 43-365 323 1-42 416-446 366-415 42 31 slipknot
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASI-----AANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGHTGSQ--------LRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis

  Help Knotoid data interpretation Full screen
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


  Help Knotoid subchains data interpretation Full screen
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 45-361 317 1-44 400-433 362-399 44 34 slipknot
view details
3.1 42-399 358 1-41 403-433 400-402 41 31 slipknot
view details
2.1 41-402 362 1-40 405-433 403-404 40 29 slipknot
view details
2.1 31-359 329 1-17, 362-433 18-30, 360-361 17 72 slipknot
view details
2.1 36-359 324 1-30, 362-433 31-35, 360-361 30 72 slipknot
sequence length 446
structure length 433
publication title The Active-Site Trimetallic Cluster of Alkaline Phosphatase is Lost Upon Isosteric Mutation at the Mg2+-Coordinating Residue Threonine-155
rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
source organism Escherichia coli
missing residues 324-328, 401-408
total genus Genus: 159
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2007-11-14
KnotProt deposition date 2014-10-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00245 Alk_phosphatase Alkaline phosphatase
B PF00245.15 Alk_phosphatase Alkaline phosphatase
B PF00245.15 Alk_phosphatase Alkaline phosphatase
B PF01663.17 Phosphodiest Type I phosphodiesterase / nucleotide pyrophosphatase
B PF01676.13 Metalloenzyme Metalloenzyme superfamily
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3bdgB00
3IGYB 1KH4A 1EW2A 3UNYA 2ANHA 1B8JA 1AJBA 4FDIA 3T02A 3SZYA 3MK2A 3T01A 3UO0A 1E2SP 1HQAA 1O98A 2GLQA 1Y7AA 3TWZA 3CMRA 1HDHA 3M8WA 1Y6VA 3UN3A 3BDGA 3OT9A 3UN5A 3MK1A 1EQJA 3M7VA 1ALJA 3MK0A 2GA3A 3BDGB 1SHNA 1ELXA 4FDJA 1E33P 3M8ZA 1P49A 1KHLA 1ED9A 1O99A 1ELZA 3ED4A 1E3CP 3TX0A 3NVLA 1ALKA 1EI6A 1EW9A 1N2KA 1ANJA 1KHNA 1KH7A 1K7HA 3DPCA 1KH9A 1ELYA 1ZEDA 3SZZA 1KH5A 1URBA 2G9YA 1FSUA 1AJDA 3BDFA 3T00A 1E1ZP 1EJJA 3BDHA 1KHJA 3M8YA 1ZEBA 1URAA 1ZEFA 1EW8A 3IGZB 2QZUA 3DYCA 1KHKA 3UN2A 1AJCA 1AUKA 1HJKA 1ED8A 1N2LA 1ALIA 2IFYA 1ANIA 1AJAA 1SHQA
chains in the KnotProt database with same CATH superfamily
3IGYB 1KH4A 1EW2A 3UNYA 2ANHA 1B8JA 1AJBA 4FDIA 3T02A 3SZYA 3MK2A 3T01A 3UO0A 1E2SP 1HQAA 1O98A 2GLQA 1Y7AA 3TWZA 3CMRA 1HDHA 3M8WA 1Y6VA 3UN3A 3BDGA 3OT9A 3UN5A 3MK1A 1EQJA 3M7VA 1ALJA 3MK0A 2GA3A 3BDGB 1SHNA 1ELXA 4FDJA 1E33P 3M8ZA 1P49A 1KHLA 1ED9A 1O99A 1ELZA 3ED4A 1E3CP 3TX0A 3NVLA 1ALKA 1EI6A 1EW9A 1N2KA 1ANJA 1KHNA 1KH7A 1K7HA 3DPCA 1KH9A 1ELYA 1ZEDA 3SZZA 1KH5A 1URBA 2G9YA 1FSUA 1AJDA 3BDFA 3T00A 1E1ZP 1EJJA 3BDHA 1KHJA 3M8YA 1ZEBA 1URAA 1ZEFA 1EW8A 3IGZB 2QZUA 3DYCA 1KHKA 3UN2A 1AJCA 1AUKA 1HJKA 1ED8A 1N2LA 1ALIA 2IFYA 1ANIA 1AJAA 1SHQA
chains in the KnotProt database with same CATH topology
3IGYB 1KH4A 1EW2A 3UNYA 2ANHA 1B8JA 1AJBA 4FDIA 3T02A 3SZYA 3MK2A 3T01A 3UO0A 1E2SP 1HQAA 1O98A 2GLQA 1Y7AA 3TWZA 3CMRA 1HDHA 3M8WA 1Y6VA 3UN3A 3BDGA 3OT9A 3UN5A 3MK1A 1EQJA 3M7VA 1ALJA 3MK0A 2GA3A 3BDGB 1SHNA 1ELXA 4FDJA 1E33P 3M8ZA 1P49A 1KHLA 1ED9A 1O99A 1ELZA 3ED4A 1E3CP 3TX0A 3NVLA 1ALKA 1EI6A 1EW9A 1N2KA 1ANJA 1KHNA 1KH7A 1K7HA 3DPCA 1KH9A 1ELYA 1ZEDA 3SZZA 1KH5A 1URBA 2G9YA 1FSUA 1AJDA 3BDFA 3T00A 1E1ZP 1EJJA 3BDHA 1KHJA 3M8YA 1ZEBA 1URAA 1ZEFA 1EW8A 3IGZB 2QZUA 3DYCA 1KHKA 3UN2A 1AJCA 1AUKA 1HJKA 1ED8A 1N2LA 1ALIA 2IFYA 1ANIA 1AJAA 1SHQA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 3IGY B;  1KH4 A;  1EW2 A;  3UNY A;  2ANH A;  1B8J A;  1AJB A;  4FDI A;  3T02 A;  3SZY A;  3MK2 A;  3T01 A;  3UO0 A;  1E2S P;  1HQA A;  1O98 A;  2GLQ A;  1Y7A A;  3TWZ A;  3CMR A;  1HDH A;  3M8W A;  1Y6V A;  3UN3 A;  3BDG A;  3OT9 A;  3UN5 A;  3MK1 A;  1EQJ A;  3M7V A;  1ALJ A;  3MK0 A;  2GA3 A;  3BDG B;  1SHN A;  1ELX A;  4FDJ A;  1E33 P;  3M8Z A;  1P49 A;  1KHL A;  1ED9 A;  1O99 A;  1ELZ A;  3ED4 A;  1E3C P;  3TX0 A;  3NVL A;  1ALK A;  1EI6 A;  1EW9 A;  1N2K A;  1ANJ A;  1KHN A;  1KH7 A;  1K7H A;  3DPC A;  1KH9 A;  1ELY A;  1ZED A;  3SZZ A;  1KH5 A;  1URB A;  2G9Y A;  1FSU A;  1AJD A;  3BDF A;  3T00 A;  1E1Z P;  1EJJ A;  3BDH A;  1KHJ A;  3M8Y A;  1ZEB A;  1URA A;  1ZEF A;  1EW8 A;  3IGZ B;  2QZU A;  3DYC A;  1KHK A;  3UN2 A;  1AJC A;  1AUK A;  1HJK A;  1ED8 A;  1N2L A;  1ALI A;  2IFY A;  1ANI A;  1AJA A;  1SHQ A; 
#chains in the KnotProt database with same CATH topology
 3IGY B;  1KH4 A;  1EW2 A;  3UNY A;  2ANH A;  1B8J A;  1AJB A;  4FDI A;  3T02 A;  3SZY A;  3MK2 A;  3T01 A;  3UO0 A;  1E2S P;  1HQA A;  1O98 A;  2GLQ A;  1Y7A A;  3TWZ A;  3CMR A;  1HDH A;  3M8W A;  1Y6V A;  3UN3 A;  3BDG A;  3OT9 A;  3UN5 A;  3MK1 A;  1EQJ A;  3M7V A;  1ALJ A;  3MK0 A;  2GA3 A;  3BDG B;  1SHN A;  1ELX A;  4FDJ A;  1E33 P;  3M8Z A;  1P49 A;  1KHL A;  1ED9 A;  1O99 A;  1ELZ A;  3ED4 A;  1E3C P;  3TX0 A;  3NVL A;  1ALK A;  1EI6 A;  1EW9 A;  1N2K A;  1ANJ A;  1KHN A;  1KH7 A;  1K7H A;  3DPC A;  1KH9 A;  1ELY A;  1ZED A;  3SZZ A;  1KH5 A;  1URB A;  2G9Y A;  1FSU A;  1AJD A;  3BDF A;  3T00 A;  1E1Z P;  1EJJ A;  3BDH A;  1KHJ A;  3M8Y A;  1ZEB A;  1URA A;  1ZEF A;  1EW8 A;  3IGZ B;  2QZU A;  3DYC A;  1KHK A;  3UN2 A;  1AJC A;  1AUK A;  1HJK A;  1ED8 A;  1N2L A;  1ALI A;  2IFY A;  1ANI A;  1AJA A;  1SHQ A; 
#chains in the KnotProt database with same CATH homology
 3IGY B;  1KH4 A;  1EW2 A;  3UNY A;  2ANH A;  1B8J A;  1AJB A;  4FDI A;  3T02 A;  3SZY A;  3MK2 A;  3T01 A;  3UO0 A;  1E2S P;  1HQA A;  1O98 A;  2GLQ A;  1Y7A A;  3TWZ A;  3CMR A;  1HDH A;  3M8W A;  1Y6V A;  3UN3 A;  3BDG A;  3OT9 A;  3UN5 A;  3MK1 A;  1EQJ A;  3M7V A;  1ALJ A;  3MK0 A;  2GA3 A;  3BDG B;  1SHN A;  1ELX A;  4FDJ A;  1E33 P;  3M8Z A;  1P49 A;  1KHL A;  1ED9 A;  1O99 A;  1ELZ A;  3ED4 A;  1E3C P;  3TX0 A;  3NVL A;  1ALK A;  1EI6 A;  1EW9 A;  1N2K A;  1ANJ A;  1KHN A;  1KH7 A;  1K7H A;  3DPC A;  1KH9 A;  1ELY A;  1ZED A;  3SZZ A;  1KH5 A;  1URB A;  2G9Y A;  1FSU A;  1AJD A;  3BDF A;  3T00 A;  1E1Z P;  1EJJ A;  3BDH A;  1KHJ A;  3M8Y A;  1ZEB A;  1URA A;  1ZEF A;  1EW8 A;  3IGZ B;  2QZU A;  3DYC A;  1KHK A;  3UN2 A;  1AJC A;  1AUK A;  1HJK A;  1ED8 A;  1N2L A;  1ALI A;  2IFY A;  1ANI A;  1AJA A;  1SHQ A;
...loading similar chains, please wait...
similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...
How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling