2GA3A

Structure of s102t e. coli alkaline phosphatase-phosphate intermediate at 2.20a resolution
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 47-369 323 1-46 419-449 370-418 46 31 slipknot
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDTAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 48-370 323 1-47 417-449 371-416 47 33 slipknot
view details
2.1 34-367 334 1-11, 371-449 12-33, 368-370 11 79 slipknot
view details
2.1 46-416 371 1-21, 422-449 22-45, 417-421 21 28 slipknot
view details
2.1 38-367 330 1-33, 371-449 34-37, 368-370 33 79 slipknot
view details
2.1 42-367 326 1-37, 371-449 38-41, 368-370 37 79 slipknot
sequence length 449
structure length 449
publication title Trapping the tetrahedral intermediate in the alkaline phosphatase reaction by substitution of the active site serine with threonine.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
source organism Escherichia coli
total genus Genus: 165
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2006-03-07
KnotProt deposition date 2014-08-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2ga3A00
4FDJA 1AJBA 1HDHA 1SHQA 1HJKA 1KHNA 1K7HA 3M8WA 3BDGA 3UN2A 1E3CP 1ED8A 3OT9A 1EW8A 1ELYA 3UO0A 1EI6A 3IGYB 3MK0A 3BDHA 3UN5A 1ED9A 1N2LA 1URAA 1SHNA 3TX0A 1B8JA 1E2SP 1ALJA 1Y7AA 1ELXA 1KH7A 1ZEFA 1HQAA 1Y6VA 2G9YA 3M8ZA 3NVLA 1EQJA 2GA3A 1ALIA 1FSUA 3TWZA 1KHKA 3BDFA 1ANIA 3ED4A 3UN3A 3BDGB 3MK1A 3DPCA 1O99A 3T00A 1N2KA 1ANJA 3DYCA 1EW2A 1O98A 1ELZA 3SZZA 1AJDA 3T02A 1URBA 1AJAA 2ANHA 1KH4A 3CMRA 3MK2A 1KH9A 2IFYA 1E33P 2QZUA 3M7VA 2GLQA 1KH5A 3IGZB 3SZYA 1KHLA 3M8YA 3T01A 1EW9A 3UNYA 1ALKA 1KHJA 1P49A 1ZEDA 1ZEBA 1AUKA 1AJCA 1EJJA 4FDIA 1ALHA 1E1ZP
chains in the KnotProt database with same CATH superfamily
4FDJA 1AJBA 1HDHA 1SHQA 1HJKA 1KHNA 1K7HA 3M8WA 3BDGA 3UN2A 1E3CP 1ED8A 3OT9A 1EW8A 1ELYA 3UO0A 1EI6A 3IGYB 3MK0A 3BDHA 3UN5A 1ED9A 1N2LA 1URAA 1SHNA 3TX0A 1B8JA 1E2SP 1ALJA 1Y7AA 1ELXA 1KH7A 1ZEFA 1HQAA 1Y6VA 2G9YA 3M8ZA 3NVLA 1EQJA 2GA3A 1ALIA 1FSUA 3TWZA 1KHKA 3BDFA 1ANIA 3ED4A 3UN3A 3BDGB 3MK1A 3DPCA 1O99A 3T00A 1N2KA 1ANJA 3DYCA 1EW2A 1O98A 1ELZA 3SZZA 1AJDA 3T02A 1URBA 1AJAA 2ANHA 1KH4A 3CMRA 3MK2A 1KH9A 2IFYA 1E33P 2QZUA 3M7VA 2GLQA 1KH5A 3IGZB 3SZYA 1KHLA 3M8YA 3T01A 1EW9A 3UNYA 1ALKA 1KHJA 1P49A 1ZEDA 1ZEBA 1AUKA 1AJCA 1EJJA 4FDIA 1ALHA 1E1ZP
chains in the KnotProt database with same CATH topology
4FDJA 1AJBA 1HDHA 1SHQA 1HJKA 1KHNA 1K7HA 3M8WA 3BDGA 3UN2A 1E3CP 1ED8A 3OT9A 1EW8A 1ELYA 3UO0A 1EI6A 3IGYB 3MK0A 3BDHA 3UN5A 1ED9A 1N2LA 1URAA 1SHNA 3TX0A 1B8JA 1E2SP 1ALJA 1Y7AA 1ELXA 1KH7A 1ZEFA 1HQAA 1Y6VA 2G9YA 3M8ZA 3NVLA 1EQJA 2GA3A 1ALIA 1FSUA 3TWZA 1KHKA 3BDFA 1ANIA 3ED4A 3UN3A 3BDGB 3MK1A 3DPCA 1O99A 3T00A 1N2KA 1ANJA 3DYCA 1EW2A 1O98A 1ELZA 3SZZA 1AJDA 3T02A 1URBA 1AJAA 2ANHA 1KH4A 3CMRA 3MK2A 1KH9A 2IFYA 1E33P 2QZUA 3M7VA 2GLQA 1KH5A 3IGZB 3SZYA 1KHLA 3M8YA 3T01A 1EW9A 3UNYA 1ALKA 1KHJA 1P49A 1ZEDA 1ZEBA 1AUKA 1AJCA 1EJJA 4FDIA 1ALHA 1E1ZP
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 4FDJ A;  1AJB A;  1HDH A;  1SHQ A;  1HJK A;  1KHN A;  1K7H A;  3M8W A;  3BDG A;  3UN2 A;  1E3C P;  1ED8 A;  3OT9 A;  1EW8 A;  1ELY A;  3UO0 A;  1EI6 A;  3IGY B;  3MK0 A;  3BDH A;  3UN5 A;  1ED9 A;  1N2L A;  1URA A;  1SHN A;  3TX0 A;  1B8J A;  1E2S P;  1ALJ A;  1Y7A A;  1ELX A;  1KH7 A;  1ZEF A;  1HQA A;  1Y6V A;  2G9Y A;  3M8Z A;  3NVL A;  1EQJ A;  2GA3 A;  1ALI A;  1FSU A;  3TWZ A;  1KHK A;  3BDF A;  1ANI A;  3ED4 A;  3UN3 A;  3BDG B;  3MK1 A;  3DPC A;  1O99 A;  3T00 A;  1N2K A;  1ANJ A;  3DYC A;  1EW2 A;  1O98 A;  1ELZ A;  3SZZ A;  1AJD A;  3T02 A;  1URB A;  1AJA A;  2ANH A;  1KH4 A;  3CMR A;  3MK2 A;  1KH9 A;  2IFY A;  1E33 P;  2QZU A;  3M7V A;  2GLQ A;  1KH5 A;  3IGZ B;  3SZY A;  1KHL A;  3M8Y A;  3T01 A;  1EW9 A;  3UNY A;  1ALK A;  1KHJ A;  1P49 A;  1ZED A;  1ZEB A;  1AUK A;  1AJC A;  1EJJ A;  4FDI A;  1ALH A;  1E1Z P; 
#chains in the KnotProt database with same CATH topology
 4FDJ A;  1AJB A;  1HDH A;  1SHQ A;  1HJK A;  1KHN A;  1K7H A;  3M8W A;  3BDG A;  3UN2 A;  1E3C P;  1ED8 A;  3OT9 A;  1EW8 A;  1ELY A;  3UO0 A;  1EI6 A;  3IGY B;  3MK0 A;  3BDH A;  3UN5 A;  1ED9 A;  1N2L A;  1URA A;  1SHN A;  3TX0 A;  1B8J A;  1E2S P;  1ALJ A;  1Y7A A;  1ELX A;  1KH7 A;  1ZEF A;  1HQA A;  1Y6V A;  2G9Y A;  3M8Z A;  3NVL A;  1EQJ A;  2GA3 A;  1ALI A;  1FSU A;  3TWZ A;  1KHK A;  3BDF A;  1ANI A;  3ED4 A;  3UN3 A;  3BDG B;  3MK1 A;  3DPC A;  1O99 A;  3T00 A;  1N2K A;  1ANJ A;  3DYC A;  1EW2 A;  1O98 A;  1ELZ A;  3SZZ A;  1AJD A;  3T02 A;  1URB A;  1AJA A;  2ANH A;  1KH4 A;  3CMR A;  3MK2 A;  1KH9 A;  2IFY A;  1E33 P;  2QZU A;  3M7V A;  2GLQ A;  1KH5 A;  3IGZ B;  3SZY A;  1KHL A;  3M8Y A;  3T01 A;  1EW9 A;  3UNY A;  1ALK A;  1KHJ A;  1P49 A;  1ZED A;  1ZEB A;  1AUK A;  1AJC A;  1EJJ A;  4FDI A;  1ALH A;  1E1Z P; 
#chains in the KnotProt database with same CATH homology
 4FDJ A;  1AJB A;  1HDH A;  1SHQ A;  1HJK A;  1KHN A;  1K7H A;  3M8W A;  3BDG A;  3UN2 A;  1E3C P;  1ED8 A;  3OT9 A;  1EW8 A;  1ELY A;  3UO0 A;  1EI6 A;  3IGY B;  3MK0 A;  3BDH A;  3UN5 A;  1ED9 A;  1N2L A;  1URA A;  1SHN A;  3TX0 A;  1B8J A;  1E2S P;  1ALJ A;  1Y7A A;  1ELX A;  1KH7 A;  1ZEF A;  1HQA A;  1Y6V A;  2G9Y A;  3M8Z A;  3NVL A;  1EQJ A;  2GA3 A;  1ALI A;  1FSU A;  3TWZ A;  1KHK A;  3BDF A;  1ANI A;  3ED4 A;  3UN3 A;  3BDG B;  3MK1 A;  3DPC A;  1O99 A;  3T00 A;  1N2K A;  1ANJ A;  3DYC A;  1EW2 A;  1O98 A;  1ELZ A;  3SZZ A;  1AJD A;  3T02 A;  1URB A;  1AJA A;  2ANH A;  1KH4 A;  3CMR A;  3MK2 A;  1KH9 A;  2IFY A;  1E33 P;  2QZU A;  3M7V A;  2GLQ A;  1KH5 A;  3IGZ B;  3SZY A;  1KHL A;  3M8Y A;  3T01 A;  1EW9 A;  3UNY A;  1ALK A;  1KHJ A;  1P49 A;  1ZED A;  1ZEB A;  1AUK A;  1AJC A;  1EJJ A;  4FDI A;  1ALH A;  1E1Z P; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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