3BDFA

Crystal structure of metal-free e. coli alkaline phosphatase (t155v)
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 159
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 47-368 322 1-46 419-449 369-418 46 31 slipknot
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDAVPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASI------ANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGTGSQLR---------IAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 47-363 317 1-46 381-434 364-380 46 54 slipknot
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3.1 47-380 334 1-46 401-434 381-400 46 34 slipknot
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2.1 45-400 356 1-44 405-434 401-404 44 30 slipknot
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2.1 45-404 360 1-44 406-434 405-405 44 29 slipknot
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2.1 17-361 345 1-8, 364-434 9-16, 362-363 8 71 slipknot
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2.1 21-361 341 1-16, 364-434 17-20, 362-363 16 71 slipknot
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2.1 38-360 323 1-20, 364-434 21-37, 361-363 20 71 slipknot
sequence length 449
structure length 434
publication title The Active-Site Trimetallic Cluster of Alkaline Phosphatase is Lost Upon Isosteric Mutation at the Mg2+-Coordinating Residue Threonine-155
rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
source organism Escherichia coli
missing residues 327-332, 404-412
total genus Genus: 159
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2007-11-14
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3bdfA00
1ALKA 1ALIA 1ANJA 1ELXA 1AJDA 3T00A 3IGZB 3BDGB 1EW2A 3MK2A 1KH7A 1URAA 3UN2A 1O99A 1KH5A 1HQAA 1O98A 1ZEBA 1EW8A 3MK1A 3MK0A 1E33P 3SZZA 1B8JA 3UN5A 1SHQA 3BDGA 3DPCA 1E1ZP 1AJAA 2IFYA 1EI6A 3M8YA 1ED9A 1KHJA 1URBA 1Y7AA 1P49A 3UO0A 1E3CP 1SHNA 1AJBA 3UNYA 1KHKA 3OT9A 1AUKA 1KHLA 1EW9A 3UN3A 1ED8A 1HJKA 2ANHA 3CMRA 1E2SP 1FSUA 2G9YA 3M8ZA 2QZUA 3IGYB 1K7HA 1ANIA 1ELZA 1AJCA 4FDIA 3DYCA 2GLQA 1N2KA 1KH4A 3M7VA 1N2LA 1ALJA 3BDFA 3T01A 1HDHA 4FDJA 3ED4A 1KH9A 1EQJA 1ELYA 1KHNA 1ZEFA 2GA3A 3M8WA 3SZYA 1EJJA 1Y6VA 3TX0A 3BDHA 3NVLA 3TWZA 3T02A 1ZEDA
chains in the KnotProt database with same CATH superfamily
1ALKA 1ALIA 1ANJA 1ELXA 1AJDA 3T00A 3IGZB 3BDGB 1EW2A 3MK2A 1KH7A 1URAA 3UN2A 1O99A 1KH5A 1HQAA 1O98A 1ZEBA 1EW8A 3MK1A 3MK0A 1E33P 3SZZA 1B8JA 3UN5A 1SHQA 3BDGA 3DPCA 1E1ZP 1AJAA 2IFYA 1EI6A 3M8YA 1ED9A 1KHJA 1URBA 1Y7AA 1P49A 3UO0A 1E3CP 1SHNA 1AJBA 3UNYA 1KHKA 3OT9A 1AUKA 1KHLA 1EW9A 3UN3A 1ED8A 1HJKA 2ANHA 3CMRA 1E2SP 1FSUA 2G9YA 3M8ZA 2QZUA 3IGYB 1K7HA 1ANIA 1ELZA 1AJCA 4FDIA 3DYCA 2GLQA 1N2KA 1KH4A 3M7VA 1N2LA 1ALJA 3BDFA 3T01A 1HDHA 4FDJA 3ED4A 1KH9A 1EQJA 1ELYA 1KHNA 1ZEFA 2GA3A 3M8WA 3SZYA 1EJJA 1Y6VA 3TX0A 3BDHA 3NVLA 3TWZA 3T02A 1ZEDA
chains in the KnotProt database with same CATH topology
1ALKA 1ALIA 1ANJA 1ELXA 1AJDA 3T00A 3IGZB 3BDGB 1EW2A 3MK2A 1KH7A 1URAA 3UN2A 1O99A 1KH5A 1HQAA 1O98A 1ZEBA 1EW8A 3MK1A 3MK0A 1E33P 3SZZA 1B8JA 3UN5A 1SHQA 3BDGA 3DPCA 1E1ZP 1AJAA 2IFYA 1EI6A 3M8YA 1ED9A 1KHJA 1URBA 1Y7AA 1P49A 3UO0A 1E3CP 1SHNA 1AJBA 3UNYA 1KHKA 3OT9A 1AUKA 1KHLA 1EW9A 3UN3A 1ED8A 1HJKA 2ANHA 3CMRA 1E2SP 1FSUA 2G9YA 3M8ZA 2QZUA 3IGYB 1K7HA 1ANIA 1ELZA 1AJCA 4FDIA 3DYCA 2GLQA 1N2KA 1KH4A 3M7VA 1N2LA 1ALJA 3BDFA 3T01A 1HDHA 4FDJA 3ED4A 1KH9A 1EQJA 1ELYA 1KHNA 1ZEFA 2GA3A 3M8WA 3SZYA 1EJJA 1Y6VA 3TX0A 3BDHA 3NVLA 3TWZA 3T02A 1ZEDA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1ALK A;  1ALI A;  1ANJ A;  1ELX A;  1AJD A;  3T00 A;  3IGZ B;  3BDG B;  1EW2 A;  3MK2 A;  1KH7 A;  1URA A;  3UN2 A;  1O99 A;  1KH5 A;  1HQA A;  1O98 A;  1ZEB A;  1EW8 A;  3MK1 A;  3MK0 A;  1E33 P;  3SZZ A;  1B8J A;  3UN5 A;  1SHQ A;  3BDG A;  3DPC A;  1E1Z P;  1AJA A;  2IFY A;  1EI6 A;  3M8Y A;  1ED9 A;  1KHJ A;  1URB A;  1Y7A A;  1P49 A;  3UO0 A;  1E3C P;  1SHN A;  1AJB A;  3UNY A;  1KHK A;  3OT9 A;  1AUK A;  1KHL A;  1EW9 A;  3UN3 A;  1ED8 A;  1HJK A;  2ANH A;  3CMR A;  1E2S P;  1FSU A;  2G9Y A;  3M8Z A;  2QZU A;  3IGY B;  1K7H A;  1ANI A;  1ELZ A;  1AJC A;  4FDI A;  3DYC A;  2GLQ A;  1N2K A;  1KH4 A;  3M7V A;  1N2L A;  1ALJ A;  3BDF A;  3T01 A;  1HDH A;  4FDJ A;  3ED4 A;  1KH9 A;  1EQJ A;  1ELY A;  1KHN A;  1ZEF A;  2GA3 A;  3M8W A;  3SZY A;  1EJJ A;  1Y6V A;  3TX0 A;  3BDH A;  3NVL A;  3TWZ A;  3T02 A;  1ZED A; 
#chains in the KnotProt database with same CATH topology
 1ALK A;  1ALI A;  1ANJ A;  1ELX A;  1AJD A;  3T00 A;  3IGZ B;  3BDG B;  1EW2 A;  3MK2 A;  1KH7 A;  1URA A;  3UN2 A;  1O99 A;  1KH5 A;  1HQA A;  1O98 A;  1ZEB A;  1EW8 A;  3MK1 A;  3MK0 A;  1E33 P;  3SZZ A;  1B8J A;  3UN5 A;  1SHQ A;  3BDG A;  3DPC A;  1E1Z P;  1AJA A;  2IFY A;  1EI6 A;  3M8Y A;  1ED9 A;  1KHJ A;  1URB A;  1Y7A A;  1P49 A;  3UO0 A;  1E3C P;  1SHN A;  1AJB A;  3UNY A;  1KHK A;  3OT9 A;  1AUK A;  1KHL A;  1EW9 A;  3UN3 A;  1ED8 A;  1HJK A;  2ANH A;  3CMR A;  1E2S P;  1FSU A;  2G9Y A;  3M8Z A;  2QZU A;  3IGY B;  1K7H A;  1ANI A;  1ELZ A;  1AJC A;  4FDI A;  3DYC A;  2GLQ A;  1N2K A;  1KH4 A;  3M7V A;  1N2L A;  1ALJ A;  3BDF A;  3T01 A;  1HDH A;  4FDJ A;  3ED4 A;  1KH9 A;  1EQJ A;  1ELY A;  1KHN A;  1ZEF A;  2GA3 A;  3M8W A;  3SZY A;  1EJJ A;  1Y6V A;  3TX0 A;  3BDH A;  3NVL A;  3TWZ A;  3T02 A;  1ZED A; 
#chains in the KnotProt database with same CATH homology
 1ALK A;  1ALI A;  1ANJ A;  1ELX A;  1AJD A;  3T00 A;  3IGZ B;  3BDG B;  1EW2 A;  3MK2 A;  1KH7 A;  1URA A;  3UN2 A;  1O99 A;  1KH5 A;  1HQA A;  1O98 A;  1ZEB A;  1EW8 A;  3MK1 A;  3MK0 A;  1E33 P;  3SZZ A;  1B8J A;  3UN5 A;  1SHQ A;  3BDG A;  3DPC A;  1E1Z P;  1AJA A;  2IFY A;  1EI6 A;  3M8Y A;  1ED9 A;  1KHJ A;  1URB A;  1Y7A A;  1P49 A;  3UO0 A;  1E3C P;  1SHN A;  1AJB A;  3UNY A;  1KHK A;  3OT9 A;  1AUK A;  1KHL A;  1EW9 A;  3UN3 A;  1ED8 A;  1HJK A;  2ANH A;  3CMR A;  1E2S P;  1FSU A;  2G9Y A;  3M8Z A;  2QZU A;  3IGY B;  1K7H A;  1ANI A;  1ELZ A;  1AJC A;  4FDI A;  3DYC A;  2GLQ A;  1N2K A;  1KH4 A;  3M7V A;  1N2L A;  1ALJ A;  3BDF A;  3T01 A;  1HDH A;  4FDJ A;  3ED4 A;  1KH9 A;  1EQJ A;  1ELY A;  1KHN A;  1ZEF A;  2GA3 A;  3M8W A;  3SZY A;  1EJJ A;  1Y6V A;  3TX0 A;  3BDH A;  3NVL A;  3TWZ A;  3T02 A;  1ZED A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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